| | 95398-45-1 Basic information More.. |
| Product Name: | A 54556A | | Synonyms: | A 54556A;PubChem ID: 24767779;A 54556A (~90%);Antibiotic A-54556A;L-Proline, N-[(2E,4E,6E)-1-oxo-2,4,6-octatrien-1-yl]-L-phenylalanyl-L-seryl-L-prolyl-N-methyl-L-alanyl-L-alanyl-4-methyl-, (6→2)-lactone, (4R)- | | CAS: | 95398-45-1 | | MF: | C38H50N6O8 | | MW: | 718.839 | | EINECS: | | | Mol File: | 95398-45-1.mol |  |
Use
A 54556A is an unusual depsipeptide isolated from Streptomyces hawaiiensis by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556A is potently active against Gram positive and Gram negative bacteria, including MRSA. A 54556A was the original lead structure of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.
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95398-45-1
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