5'-Amino-2'-hydroxyacetophenone

5'-Amino-2'-hydroxyacetophenone Suppliers list
Company Name: Capot Chemical Co., Ltd  
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Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Tel: 021-54306202 13764082696
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Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
Tel: 400-6206333 13167063860
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Company Name: SynAsst Chemical.  
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Company Name: Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.  
Tel: 0515-89701588 13770166955
Email: orgunion@orgunion.com

5'-Amino-2'-hydroxyacetophenone manufacturers

5'-Amino-2'-hydroxyacetophenone Basic information
Product Name:5'-Amino-2'-hydroxyacetophenone
Synonyms:1-(5-Amino-2-hydroxyphenyl);5''-AMINO-2''-HYDROXYACETOPHENONE {1-(5-AMINO-2-HYDROXYPHENYL)ETHANONE};Ethanone, 1-(5-amino-2-hydroxyphenyl)-;5'-Amino-2'-hydroxyacetophenone
CAS:50-80-6
MF:C8H9NO2
MW:151.16
EINECS:
Product Categories:
Mol File:50-80-6.mol
5'-Amino-2'-hydroxyacetophenone Structure
5'-Amino-2'-hydroxyacetophenone Chemical Properties
Melting point 121–122°C
Boiling point 335.4±27.0 °C(Predicted)
density 1.242±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka10.42±0.18(Predicted)
AppearanceLight yellow to yellow Solid
Safety Information
HS Code 2914500090
MSDS Information
5'-Amino-2'-hydroxyacetophenone Usage And Synthesis
Uses1-(5-Amino-2-hydroxyphenyl)ethanone is used in the preparation of alkylated flavonoid compounds for use as therapeutic antioxidants. It is also used to synthesize spiro[chromanone-piperidine]s as acetyl-CoA carboxylase inhibitors.
PreparationAlso obtained by refluxing a suspension of N-(3-acetyl-4- hydroxyphenyl)acetamide in 15% hydrochloric acid for 40 min (84%).
Synthesis
N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE

7298-67-1

5'-Amino-2'-hydroxyacetophenone

50-80-6

The hydrolysis reaction was carried out by refluxing 2-hydroxy-5-acetamidoacetophenone in 2N hydrochloric acid solution for 6 hours to obtain 5-amino-2-hydroxyacetophenone in 94% yield.

References[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 21, p. 3973 - 3976
[2] Patent: US2007/117823, 2007, A1. Location in patent: Page/Page column 8
[3] Patent: WO2007/54580, 2007, A1. Location in patent: Page/Page column 16
[4] European Journal of Medicinal Chemistry, 1991, vol. 26, # 9, p. 843 - 851
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2079 - 2098
5'-Amino-2'-hydroxyacetophenone Preparation Products And Raw materials
Raw materialsN1-(3-Acetyl-4-hydroxyphenyl)acetamide
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