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| | 1-Azetidinesulfonamide(9CI) Basic information |
| | 1-Azetidinesulfonamide(9CI) Chemical Properties |
| Boiling point | 276.3±23.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 11.52±0.20(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C3H8N2O2S/c4-8(6,7)5-2-1-3-5/h1-3H2,(H2,4,6,7) | | InChIKey | STIUWSWFXIBBKI-UHFFFAOYSA-N | | SMILES | N1(S(N)(=O)=O)CCC1 |
| | 1-Azetidinesulfonamide(9CI) Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 1-azetidinylsulfonamide using the compound (CAS:1271835-78-9) as starting material was as follows: palladium hydroxide (20%, 350 mg), benzyl (azetidin-1-ylsulfonyl) carbamate (1.49 g, 5.5 mmol), and 1-methyl-1,4-cyclohexadiene (10.7 g, 0.11 mol) of the The mixture was dissolved in methanol (35 mL) and the reaction was stirred at 60 °C under nitrogen protection overnight. After completion of the reaction, the mixture was cooled to room temperature, filtered through a diatomaceous earth pad, and the filtrate was concentrated in vacuum to afford 1-azetidinesulfonamide (437 mg, 58% yield) as a solid product. The product was characterized by 1H NMR (400 MHz, CD3OD) with chemical shifts δ of 2.15 (quintuple peak, 2H) and 3.78 (triplet peak, 4H).The corresponding mass ions were not detected by LCMS analysis. | | References | [1] Patent: WO2013/88315, 2013, A1. Location in patent: Page/Page column 75
[2] Patent: WO2013/102826, 2013, A1. Location in patent: Page/Page column 91 |
| | 1-Azetidinesulfonamide(9CI) Preparation Products And Raw materials |
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