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化学名: | マロン酸エチルカリウム | 英語化学名: | Ethyl potassium malonate | 别名: | AKOS 310;ETHYL POTASSIUM MALONATE;ETHYL MALONATE MONOPOTASSIUM SALT;ETHYL MONO POTASSIUM MALONATE;KEM;MALONIC ACID MONOETHYL ESTER POTASSIUM;MALONIC ACID MONOETHYL ESTER POTASSIUM SALT 98+%;Ethylpotassiummalonate,98% | CAS番号: | 6148-64-7 | 分子式: | C5H7KO4 | 分子量: | 170.2 | EINECS: | 228-156-7 | カテゴリ情報: | Pharmaceutical Intermediates;bc0001;6148-64-7 | Mol File: | 6148-64-7.mol | |
融点 | 194 °C (dec.) (lit.) | 貯蔵温度 | Inert atmosphere,Room Temperature | 溶解性 | Methanol (Slightly), Water (Slightly) | 外見 | Powder or Cyrstals | 色 | White | PH | pH(50g/l, 25℃) : 5.5~8.0 | 水溶解度 | soluble | Sensitive | Hygroscopic | BRN | 3721682 | InChIKey | WVUCPRGADMCTBN-UHFFFAOYSA-M | CAS データベース | 6148-64-7(CAS DataBase Reference) |
| マロン酸エチルカリウム Usage And Synthesis |
外観 | 白色〜ほとんど白色, 結晶〜結晶性粉末又は塊 | 溶解性 | 水及びエタノールに溶け、アセトンにほとんど溶けない。 | 使用上の注意 | アルゴン封入 | 化学的特性 | white crystals or powder | 使用 | Ethyl potassium malonate (potassium ethyl malonate) may be used to generate (trimethylsilyl)ethyl malonate in situ, which can be acylated to prepare a variety of β-ketoesters or alkylidene malonates. | 使用 | Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation. Further, it reacts with aryl nitriles to prepare beta-amino acrylates in the presence of zinc chloride and a catalytic amount of Hünig's base. In addition to this, it serves as an intermediate for the preparation of ethyl tert-butyl malonate. | 一般的な説明 | Ethyl potassium malonate (potassium ethyl malonate) reacts with aryl nitriles in the presence of zinc chloride and a catalytic amount of Hünig′s base to yield β-amino acrylates. Ethyl potassium malonate is formed as an intermediate during the synthesis of ethyl tert-butyl malonate. |
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