C3A (70-77),ASHLGLAR
| 中文名称 | C3A (70-77),ASHLGLAR |
|---|---|
| 中文同义词 | C3A (70-77),ASHLGLAR;补体C3a(70-77);Mouse Monoclonal Antibody to C3C抗体(别名:ASP;化合物C3a 70-77;大鼠补体成分3a(C3a)ELISA试剂盒 YB-71451Ra |
| 英文名称 | C3A (70-77) |
| 英文同义词 | C3A (70-77);ASHLGLAR;H-ALA-SER-HIS-LEU-GLY-LEU-ALA-ARG-OH;ALA-SER-HIS-LEU-GLY-LEU-ALA-ARG;ANAPHYLATOXIN C3A FRAGMENT 70-77;Complement C3a, (70-77);complement 3a (70-77);alanine-serine-histidine-leucine-glycine-leucine-alanine- |
| CAS号 | 63555-63-5 |
| 分子式 | C35H61N13O10 |
| 分子量 | 823.94 |
| EINECS号 | |
| 相关类别 | 多肽;细胞系-human细胞系;细胞-细胞系;试剂盒-ELISA试剂盒;生化试剂;目录多肽;试剂盒;peptide |
| Mol文件 | 63555-63-5.mol |
| 结构式 |  |
C3A (70-77),ASHLGLAR 性质
| 密度 | 1.44±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.34±0.10(Predicted) |
| 序列 | Ala-Ser-His-Leu-Gly-Leu-Ala-Arg |
Complement system
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10
-7
M or higher and exceeds 75% at 10
-6
M, irrespective of the stimulus.
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.
安全信息
| WGK Germany | 3 |
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| 提供商 | 语言 |
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英文
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