ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate manufacturers
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| | ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate Basic information |
| Product Name: | ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate | | Synonyms: | ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate;Benzenebutanoic acid, 4-fluoro-.alpha.,.gaMMa.-dioxo-, ethyl ester;Ethyl 4-fluoro-a,g-dioxo-benzenebutanoate;Ethyl 4-(4-fluorophenyl);4-(4-Fluoro-phenyl)-2,4-dioxo-butyric acid ethyl ester;Benzenebutanoic acid, 4-fluoro-α,γ-dioxo-, ethyl ester;Benzenebutanoicacid,4-fluoro-α,γ-dioxo-,ethylester;ETHYL-4-(4-FLOURO PHENYL)-2,4-DI OXO BUTANOATE | | CAS: | 31686-94-9 | | MF: | C12H11FO4 | | MW: | 238.21 | | EINECS: | | | Product Categories: | | | Mol File: | 31686-94-9.mol |  |
| | ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate Chemical Properties |
| Boiling point | 360.9±22.0 °C(Predicted) | | density | 1.241±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 6.00±0.25(Predicted) | | Appearance | Light yellow to yellow Solid |
| | ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate Usage And Synthesis |
| Synthesis | Synthesis of ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate: In a 2L round-bottomed flask fitted with a reflux condenser tube and a CaCl2 drying tube, sodium metal (49.9 g, 2.17 mol, 3.0 eq.) was slowly dissolved in ethanol (1.0 L). After the resulting sodium ethanol solution was cooled to about 10°C, a mixture of 4-fluoroacetophenone (100.0 g, 0.72 mol) and diethyl oxalate (295 mL, 2.17 mol, 3.0 eq.) was slowly added. The reaction mixture was stirred for about 15 minutes and then placed in a refrigerator to stand overnight. Subsequently, the reaction mixture was poured into a mixture consisting of concentrated hydrochloric acid solution (300 mL) and ice (about 1 kg). The resulting precipitate was collected by filtration and washed with plenty of water and finally dried in a vacuum dryer using P2O5/KOH. The product was a light yellow powder, yield: 165.5 g (96% yield). | | References | [1] Patent: WO2015/95337, 2015, A2. Location in patent: Paragraph 0030
[2] Synthetic Communications, 2013, vol. 43, # 1, p. 110 - 117
[3] Patent: WO2015/196071, A1. Location in patent: Paragraph 0520
[3] Patent: , 2015, . Location in patent: Paragraph 0520
[5] Patent: WO2017/40606, 2017, A1. Location in patent: Paragraph 0465 |
| | ethyl 4-(4-fluorophenyl)-2,4-dioxobutanoate Preparation Products And Raw materials |
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