| 外観 | うすい黄色～褐色～暗い緑色粉末～塊 |
| 溶解性 | 水に不溶, エタノール, エーテルに易溶。エタノール及びアセトンに溶けやすく、水に極めて溶けにくい。 |
| 用途 | 有機合成の中間体、染料、医薬品の中間体 |
| 化学的特性 | beige crystalline solid. soluble in alcohol, ether and boiling petroleum ether, slightly soluble in cold petroleum ether, insoluble in water. |
| 使用 | o-Isomer as dye intermediate; in organic syntheses. |
| 使用 | 4-Nitroanisole is an intermediate in the manufacture of azo dyes. A toxic organic pollutant and a risk factor for urinary bladder cancer in humans. |
| 定義 | ChEBI: 4-nitroanisole is a member of the class of 4-nitroanisoles that is anisole in which one the hydrogen meta to the methoxy group is replaced by a nitro group. |
| 製造方法 | Produced from p-nitrochlorobenzene by methoxylation. |
| Synthesis Reference(s) | Synthetic Communications, 25, p. 1367, 1995 DOI: 10.1080/00397919508013838
Tetrahedron Letters, 14, p. 1397, 1973 |
| 一般的な説明 | A light red or amber-colored liquid or crystals. Insoluble in water and denser than water. Contact may irritate skin, eyes and mucous membranes. May be toxic by ingestion, inhalation or skin absorption. Used to make other chemicals. |
| 空気と水の反応 | Insoluble in water. |
| 反応プロフィール | 4-Nitroanisole reacts explosively with (sodium hydroxide + zinc). 4-Nitroanisole reacts vigorously with hydrogen + catalyst (at 482° F and 25500 mm Hg). |
| 健康ハザード | Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. |
| 火災危険 | Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. |
| Biochem/physiol Actions | 4-Nitroanisole is O-demethylated to 4-nitrophenol by human liver microsomes. |
| 安全性プロファイル | A poison by ingestion.
Mutation data reported. Can explode in
presence of Ni. When heated to
decomposition it emits toxic fumes of NOx.
See also o-NITROANISOLE and NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS. |
| 純化方法 | Crystallise it from pet ether or hexane and dry it in vacuo. [Beilstein 6 IV 1282.] |