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Drostanolone propionate

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CAS:521-12-0
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  • Drostanolone Propionate
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  • 2022-01-20
  • CAS:521-12-0
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Related articles

  • What is Drostanolone propionate?
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  • Feb 20,2020
Drostanolone propionate Basic information
Antiestrogenic effects Physiological effect
Product Name:Drostanolone propionate
Synonyms:Drostanolone propioante;DroMostanolone Enanthate(Masteron);17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate;17β-Hydroxy-2α-methylandrostan-3-one propionate;2α-Methyl-17β-hydroxy-5α-androstan-3-one 17-propionate;2α-Methyl-17β-propionoxy-5α-androstan-3-one;2α-Methyl-4,5-dihydrotestosterone propionate;2α-Methylandrostan-17(β)-ol-3-one propionate
CAS:521-12-0
MF:C23H36O3
MW:360.54
EINECS:208-303-1
Product Categories:materon;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone
Mol File:521-12-0.mol
Drostanolone propionate Structure
Drostanolone propionate Chemical Properties
Melting point 114-120°C
alpha D +24°
Boiling point 432.53°C (rough estimate)
density 1.0669 (rough estimate)
refractive index 1.4700 (estimate)
storage temp. Controlled Substance, -20°C Freezer
CAS DataBase Reference521-12-0(CAS DataBase Reference)
NIST Chemistry ReferenceDromostanolone propionate(521-12-0)
Safety Information
ToxicityLD50 subcutaneous in mouse: > 2gm/kg
MSDS Information
Drostanolone propionate Usage And Synthesis
Antiestrogenic effectsDromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness.
Drostanolone propionate is a modified form of drostanolone, where a carboxylic acid ester (propionic acid) has been attached to the 17-beta hydroxyl group.Drostanolone Propionate is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone.
Physiological effectLike testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Specifically, Masteron is the DHT hormone that has been structurally altered by the addition of a methyl group at the carbon 2 position, This protects the hormone from the metabolic breakdown by the 3-hydroxysteroid dehydrogenase enzyme, which is found in the skeletal muscle.
Description17b-Hydroxy-2a-methyl-5a-androstan-3-one propionate, also known as drostanolone propionate, is a synthetic anabolic-androgenic steroid. It has similar properties to dihydrotestosterone. It had been used for the treatment of breast cancer in the past. However, it is now mainly used by athletes and bodybuilder as an anabolic steroid. It has two major effects including enhancing the physical/athletic performance (such as endurance and strength) and enhancing physical health (muscle buildup and fat loss). It should be administrated via intramuscular injection instead of oral taking.
Chemical PropertiesWhite Solid
OriginatorDrolban,Lilly,US,1961
UsesAn anabolic steroid used as an antineoplastic.
Manufacturing ProcessA suspension of 10 grams of dihydrotestosterone in 500 cc of anhydrous benzene free of thiophene was mixed with10 cc of ethyl formate and 3 grams of sodium hydride and the mixture was stirred for 5 hours under an atmosphere of nitrogen and at a temperature of approximately 25°C. The resulting suspension was filtered, the resulting mixture of the sodium salt of the hydroxymethylene compound and the excess of sodium hydride was washed with benzene and dried. This mixture was slowly added to a vigorously stirred solution of 20 cc of concentrated hydrochloric acid in 500 cc of water, and the stirring was continued for 30 minutes at the end of which the precipitate was collected and well washed with distilled water. After drying in vacuo, there was obtained 9.7 grams of 2-hydroxymethylenedihydrotestosterone.
A mixture of 1 gram of 2-hydroxymethylene-dihydrotestosterone, 10 cc of pyridine and 2 cc of propionic anhydride was allowed to react at room temperature for 16 hours and then poured into water. The resulting suspension was heated for 1 hour on the steam bath to hydrolyze the excess of propionic anhydride, cooled and extracted with methylene dichloride. The extract was consecutively washed with dilute hydrochloric acid, sodium bicarbonate solution and water, dried over anhydrous sodium sulfate and evaporated to dryness under vacuum. There was thus obtained the dipropionate of 2-hydroxymethylenedihydrotestosterone which was treated with hydrogen, in methanol solution.
When the uptake of hydrogen ceased, the catalyst was filtered and the solution was evaporated to dryness under vacuum. The residue was dissolved in a mixture of benzene-hexane, transferred to a chromatographic column with neutral alumina and the product was eluted with mixtures of benzenehexane, gradually increasing the proportion of benzene in the mixture. Crystallization of the eluates from acetone-hexane yielded the propionate of 2α-methyldihydrotestosterone.
Brand nameDrolban (Lilly).
Therapeutic FunctionCancer chemotherapy
Referenceshttps://en.wikipedia.org/wiki/Drostanolone_propionate
http://www.chemspider.com/Chemical-Structure.194604.html
http://steroid.es/drostanolone.html
Chowdhury, M. S., et al. "A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca-durabolin) in the treatment of breast carcinoma. " 2.3(1976):203-206.
Drostanolone propionate Preparation Products And Raw materials
Raw materialsStanolone-->Propionic anhydride-->Ethyl formate-->Sodium hydride
Tag:Drostanolone propionate(521-12-0) Related Product Information
Stanozolol Trenbolone acetate Methenolone acetate Methenolone enanthate Methoxydienone Nandrolone phenylpropionate Nandrolone Decanoate Nandrolone Drostanolone enanthate Chrysene Methyl propionate Androsterone Testosterone 17a-Methyl-Drostanolone Drostanolone propionate Stanolone 17beta-hydroxy-5alpha-androstan-3-one propionate Dromostanolone