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| | AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2 Basic information |
| Product Name: | AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2 | | Synonyms: | ACETYL-(D-ARG10, CYS11, D-PHE14, CYS17)-BETA-MSH (10-17) AMIDE;AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2;AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2, (DISULFIDE BOND);Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-b-MSH (10-17) aMide;Reaxys ID: 14573809;Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-b-MSH (10-17) amide trifluoroacetate salt;52:PN:WO2005000339 SEQID:52 claimed sequence;Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide | | CAS: | 819048-44-7 | | MF: | C51H72N18O11S2 | | MW: | 1177.36 | | EINECS: | | | Product Categories: | | | Mol File: | 819048-44-7.mol |  |
| | AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2 Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 4.47±0.10(Predicted) | | form | lyophilized powder | | color | white to off-white | | Sequence | Ac-{d-Arg}-Cys-Glu-His-{d-Phe}-Arg-Trp-Cys-NH2 (Disulfide bridge: Cys2-Cys8) |
| | AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2 Usage And Synthesis |
| Uses | Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1]. | | Biological Activity | LY2112688 is a beta-melanocyte-stimulating hormone (β-MSH)-derived peptide th at acts as a high-affinity, potent and selective melanocortin receptor 4 (MC-4, MC-4R, MC4-R, MC4R) agonist (human/r at MC-4 Ki = 0.55/0.39 nM; human MC-1/3/5 Ki = 16.78/56.79/>500 nM). LY2112688 selectively induces MC-4-mediated cAMP release (MC-4/3 EC50 = 0.25 nM/1.61 nM, MC-4/3 Emax = 94.5%/84.1% of NDP-α-MSH Emax using HEK293 expressing respective human receptors) and exhibits in vivo efficacy in reducing daily food intake and promoting weight loss among diet-induced obese rats (75 & 299 nmol/kg/day s.c.). | | References | [1] Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065. DOI:10.1021/acs.jmedchem.0c02041 |
| | AC-D-ARG-CYS-GLU-HIS-D-PHE-ARG-TRP-CYS-NH2 Preparation Products And Raw materials |
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