| Company Name: |
Ontores Biotech |
| Tel: |
0571-88760729 18072970094 |
| Email: |
supports@ontorespeptide.com |
|
| Product Name: | TH | | Synonyms: | Anti-th antibody produced in rabbit;Anti-TH (C-terminal) antibody produced in goat;TYROSINE HYDROXYLASE;TH;Anti-TYH;Human TH Protein, His Tag;γ-Aminobutyric Acid (GABA) Colorimetric Assay Kit;DYT14 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | Elisa Kit-Mouse Elisa Kit | | Mol File: | Mol File | ![TH Structure]() |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | WGK 2 | | Storage Class | 12 - Non Combustible Liquids |
| Description | An enzyme that is located in catecholamine-synthesizing cells and is responsible
for the hydroxylation of L-tyrosine to L 3,4-dihydroxyphenylalanine (L-dopa). This is the initial and rate-limiting step in the biosynthetic pathway for catecholamines (dopamine, norepinephrine, and epinephrine). In addition to hydroxylating tyrosine using biopterin as a coenzyme, this enzyme can also
hydroxylate phenylalanine to tyrosine. The enzyme is located in the cytosol of catecholamine neurons and has a Km for tyrosine that is in the micromolar range. | | Uses | Anti-th antibody produced in rabbit has been used in:
- western blotting (1:1000)
- whole retinal flat-mount immunolabelling (1:500)
- immunofluorescence (2:1000)
- immunohistochemistry (2:1000)
| | General Description | Tyrosine hydroxylase(TH) is a cytoplasmic enzyme. The TH gene codes for a monooxygenase. | | Biochem/physiol Actions | Cell surface-associated protein is implicated in virulence. Promotes bacterial attachment exclusively to the γ-chain of human fibrinogen. Induces formation of bacterial clumps, which diminish the ability of group IIA phospholipase A2 to cause bacterial phospholipid hydrolysis and killing. Significantly decreases macrophage phagocytosis possibly thanks to the clumps, clumped bacteria being too large to be phagocytosed. Dominant factor responsible for human platelet aggregation, which may be an important mechanism for initiating infective endocarditis. Enhances spleen cell proliferative response in vitro, contributing significantly to the immunostimulatory activity of S.aureus. |
| | TH Preparation Products And Raw materials |
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