1,3-二咖啡酰奎宁酸
中文名称 | 1,3-二咖啡酰奎宁酸 |
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中文同义词 | 1,3-二咖啡酰奎宁酸 19870-46-3;1,3-二咖啡酰奎宁酸;1,3-二咖啡酰奎宁酸,对照品,;洋蓟素、朝蓟素;化合物GNE9605;(1S,3R,4R,5R)-1,3-O-二咖啡酰奎宁酸;1,5-二咖啡酰奎宁酸(洋蓟酸,菜蓟素,朝蓟素,朝鲜蓟酸,1,5-O-二咖啡酰奎宁酸);CYNARIN|||1,3-二咖啡酰奎宁酸|||CYCLOHEXANECARBOXYLI?C ACID, 1,?3-?BIS[[3-?(3,?4-?DIHYDROXYPHENYL)?-?1-?OXO-?2-?PROPEN-?1-?YL]?OXY]?-?4,?5-?DIHYDROXY-?, (1S,?3R,?4R,?5R)?-|||1,3-O-DICAFFEOYLQUINIC ACID|||1,5-DICAFFEOYLQUINIC ACID |
英文名称 | CYNARIN |
英文同义词 | 1,3-Dicaffeoylquinic acid;(1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid;Dicaffeoylquinic Acid, 1,5-;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid;1,5-di-O-Caffeoylquinic acid;Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci;19870-46-3 CYNARIN |
CAS号 | 19870-46-3 |
分子式 | C25H24O12 |
分子量 | 516.45 |
EINECS号 | 214-655-7 |
相关类别 | 标准品;对照品,标准品;其他生化试剂;标准品-中药标准品;标准品,对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 19870-46-3.mol |
结构式 |
1,3-二咖啡酰奎宁酸 性质
沸点 | 819.9±65.0 °C(Predicted) |
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密度 | 1?+-.0.1 g/cm3(Predicted) |
储存条件 | Keep in dark place,Sealed in dry,2-8°C |
溶解度 | 可溶5mg/mL,澄清,无色至浅黄色 |
形态 | 固体 |
酸度系数(pKa) | 2.50±0.50(Predicted) |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
1,3-二咖啡酰奎宁酸是一种抗高脂血症的药物。此外,作为神经保护剂对抗淀粉样蛋白-β毒性治疗阿尔茨海默病。
1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物,具有抗氧化活性和自由基清除活性。
Akt
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PI3K
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1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons. 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A). 1,3-Dicaffeoylquinic acid's anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax. 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.
1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.
药理药效:具有氧化、抗炎、抗病毒、抗纤维化、抑制平滑肌收缩、降血脂等诸多作用。
安全信息
WGK Germany | 3 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | S9512 | 1,3-二咖啡酰奎宁酸 1,3-Dicaffeoylquinic acid | 19870-46-3 | 1mg | 1204.48元 |