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| | COMPOUND 401 Basic information |
| Product Name: | COMPOUND 401 | | Synonyms: | 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one;4H-PyriMido[2,1-a]isoquinolin-4-one, 2-(4-Morpholinyl)-;2-(Morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one;2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one;Compound 401, >=98%;2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one;CS-315;COMPOUND401;COMPOUND-401 | | CAS: | 168425-64-7 | | MF: | C16H15N3O2 | | MW: | 281.31 | | EINECS: | | | Product Categories: | | | Mol File: | 168425-64-7.mol |  |
| | COMPOUND 401 Chemical Properties |
| Melting point | 184-186℃ (ethanol ) | | Boiling point | 456.9±55.0 °C(Predicted) | | density | 1.36±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | Store at RT | | solubility | DMSO : 6 mg/mL (21.33 mM; Need ultrasonic and warming) | | pka | 1.01±0.20(Predicted) | | form | powder to crystal | | color | White to Light yellow | | InChI | 1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2 | | InChIKey | BVRDQVRQVGRNHG-UHFFFAOYSA-N | | CAS DataBase Reference | 168425-64-7 |
| WGK Germany | WGK 1 | | HS Code | 2934.99.4400 | | Storage Class | 11 - Combustible Solids |
| | COMPOUND 401 Usage And Synthesis |
| Uses | Compound 401 is a selective inhibitor of DNA-PK and FRAP. | | Biological Activity | Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC 50 values are 0.28 and 5.3 μ M respectively). Displays little affinity for other commonly studied kinases including PI 3-K, ATM and ATR (IC 50 values are all > 100 μ M). Induces apoptosis in vitro . | | IC 50 | DNA-PK: 0.28 μM (IC50); mTOR: 5.3 μM (IC50) |
| | COMPOUND 401 Preparation Products And Raw materials |
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