5-氯-2-脱氧尿嘧啶核苷
| 中文名称 | 5-氯-2-脱氧尿嘧啶核苷 |
|---|---|
| 中文同义词 | 5-氯-2'-脱氧尿苷;5-氯-2-脱氧尿嘧啶核苷;5-氯脱氧尿苷;5-氯-2'-脱氧尿苷/尿苷;5-CHLORO-2'-DEOXYURIDINE 5-氯-2-脱氧尿嘧啶核苷;5-氯-1-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-)嘧啶-2,4(1H,3H)-二酮 |
| 英文名称 | 5-CHLORO-2'-DEOXYURIDINE |
| 英文同义词 | 2'-DEOXY-5-CHLOROURIDINE;5-CHLORODESOXYURIDINE;5-CHLORO-2'-DEOXYURIDINE;5-chloro-2’-deoxy-uridin;5-Chlorodeoxyuridin;5-Chloro-2'-deoxy-D-uridine;5-CHLORODEOXYURIDINE;Chlorodeoxyuridine |
| CAS号 | 50-90-8 |
| 分子式 | C9H11ClN2O5 |
| 分子量 | 262.65 |
| EINECS号 | |
| 相关类别 | 核苷;API intermediates;Bases & Related Reagents;Carbohydrates & Derivatives;Heterocycles;Nucleotides;Biochemicals and Reagents;Nucleoside Analogs;Nucleosides, Nucleotides, Oligonucleotides |
| Mol文件 | 50-90-8.mol |
| 结构式 |  |
5-氯-2-脱氧尿嘧啶核苷 性质
| 熔点 | 176-179°C |
|---|---|
| 密度 | 1.5507 (rough estimate) |
| 折射率 | 1.6500 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | DMSO（少许）、甲醇（少许）、水（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 7.73±0.10(Predicted) |
| 颜色 | 白色至类白色 |
| CAS 数据库 | 50-90-8(CAS DataBase Reference) |
5-Chloro-2'-deoxyuridine，一个胸腺嘧啶的类似物，可用于研究次氯酸对 DNA 和 DNA 前体的破坏作用。
When 5-Chloro-2’-deoxyuridine (ClDU) is placed into tissue culture medium, mammalian cells incorporate the analog into DNA. It is observed that 10 μM concentration of 5-Chloro-2’-deoxyuridine in the media does not alter cell division kinetics. Previously it has been shown that 5-Chloro-2’-deoxyuridine is metabolized and incorporated into DNA using antibodies that bind selectively to DNA containing halogenated bases. In the studies reported here, 5-Chloro-2’-deoxyuridine is more similar to BrdU in acting as a T analog. The toxicity of 5-Chloro-2’-deoxyuridine could in part be attributed to inhibition of thymidylate synthase.
类别
有毒物质毒性分级
中毒急性毒性
腹腔-大鼠 LD50: 2000 毫克/公斤可燃性危险特性
可燃; 火场释放有毒氮氧化物, 氯化物烟雾储运特性
库房低温通风干燥灭火剂
水, 二氧化碳, 泡沫, 沙土安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21/22-40 |
| 安全说明 | 36/37/39-45 |
| WGK Germany | 3 |
| RTECS号 | YU7400000 |
| 海关编码 | 29349990 |
| 提供商 | 语言 |
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英文
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