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Product Name:Ro 67-7476
CAS:298690-60-5
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| | Ro 67-7476 Basic information |
| Product Name: | Ro 67-7476 | | Synonyms: | Ro 67-7476;Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl) sulfonyl]-, (2S)-;(2S)-2-(4-Fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-pyrrolidine;RO67-7476;RO-67-7476;excitatory postsynaptic potentials,Ro 67-7476,cAMP accumulation,mGluR,neuronal culture,Metabotropic glutamate receptors,Ro 67 7476,inhibit,Ro 677476,traumatic injury,mGluR1,Inhibitor | | CAS: | 298690-60-5 | | MF: | C17H18FNO2S | | MW: | 319.39 | | EINECS: | | | Product Categories: | | | Mol File: | 298690-60-5.mol |  |
| | Ro 67-7476 Chemical Properties |
| Boiling point | 452.9±55.0 °C(Predicted) | | density | 1.268±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | DMSO:30.0(Max Conc. mg/mL);93.9(Max Conc. mM) | | pka | -5.53±0.40(Predicted) | | form | Powder |
| | Ro 67-7476 Usage And Synthesis |
| Description | Ro 67-7476 is a positive allosteric modulator of metabotropic glutamate receptor 1 (mGluR1) that enhances glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a (EC50 = 1.74 μM). It is selective for rat mGluR1 over rat mGluR2, mGluR4, and mGluR8 at a concentration of 10 μM. Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5 in the Purkinje cells of rat cerebellar slices. It activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50 = 163.3 nM). | | Uses | Ro 67-7476 is a positive allosteric metabotropic mGlu1 receptor modulator. | | storage | Store at RT |
| | Ro 67-7476 Preparation Products And Raw materials |
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