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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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| Products Intro: |
Product Name:SynaptaMide-d4
CAS:946524-43-2
Package:2.5Mg,25Mg
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| Company Name: |
Yichang Zhongyitai Trading Co., Ltd.
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0717-6449896 13886658719 |
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| Products Intro: |
Product Name:DHA Ethanolamide-d4
CAS:946524-43-2
Purity:98+% Package:5mg
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:Docosahexaenoyl Ethanolamide-d4
CAS:946524-43-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Synaptamide-d4
CAS:946524-43-2
Purity:>95% Package:10mg
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| | Docosahexaenoyl Ethanolamide-d4 Basic information |
| Product Name: | Docosahexaenoyl Ethanolamide-d4 | | Synonyms: | Docosahexaenoyl Ethanolamide-d4;SynaptaMide-d4;GEEHOLRSGZPBSM-DXYZWJMHSA-N;(4Z,7Z,10Z,13Z,16Z,19Z)-N-(1,1,2,2-tetradeuterio-2-hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide;DHA Ethanolamide-d4 | | CAS: | 946524-43-2 | | MF: | C24H33D4NO2 | | MW: | 375.580727112 | | EINECS: | | | Product Categories: | | | Mol File: | 946524-43-2.mol |  |
| | Docosahexaenoyl Ethanolamide-d4 Chemical Properties |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.15 mg/ml |
| | Docosahexaenoyl Ethanolamide-d4 Usage And Synthesis |
| Description | Docosahexaenoyl ethanolamide-d4 contains four deuterium atoms at the 1, 1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of docosahexaenoyl ethanolamide by GC- or LC-mass spectrometry (MS). Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for arachidonoyl ethanolamide (AEA).1,2 A 9.5 fold increase of DHEA was observed in brain lipid extracts from piglets fed a diet supplemented with DHA compared to a control diet without DHA.3 DHEA binds to the rat brain CB1 receptor with a Ki value of 324 nM, which is approximately 10-fold higher than the Ki value for AEA.4 DHEA inhibits shaker-related voltage-gated potassium channels in brain slightly better than AEA, with an IC50 value of 1.5 μM.5 | | Uses | Synaptamide-d4 is labelled Synaptamide (S910000) which is an endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. It has potent synaptogenic activity and structural similarity to anandamide. Synaptamide (S910000) is subjected to hydrolysis by fatty acid amide hydrolase, and can be oxygenated to bioactive metabolites. | | References | 1. Sugiura, T., Kondo, S., Sukagawa, A., et al. Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamine Eur. J. Biochem. 240,53-62(1996).
2. Bisogno, T., Delton-Vandenbroucke, I., Milone, A., et al. Biosynthesis and inactivation of N-Arachidonoylethanolamine (Ananadamide) and N-Docosahexaenoylethanolamine in bovine retina Arch. Biochem. Biophys. 370(2),300-307(1999).
3. Berger, A., Crozier, G., Bisogno, T., et al. Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets Proc. Natl. Acad. Sci. USA 98(11),6402-6406(2001).
4. Sheskin, T., Hanus, L., Slager, J., et al. Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor J. Med. Chem. 40,659-667(1997).
5. Poling, J.S., Rogawski, M.A., Salem, N., Jr., et al. Anadamide, an endogenous cannabinoid, inhibits shaker-related voltage-gated K+ channels Neuropharmacology 35(7),983-991(1996). |
| | Docosahexaenoyl Ethanolamide-d4 Preparation Products And Raw materials |
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