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| 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Basic information |
Product Name: | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide | Synonyms: | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide;THP-sulfonamide;3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide;abt-1-199;3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide;Venetoclax Intermediate;Benzenesulfonamide, 3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]-;ABT-199 intermedate3 | CAS: | 1228779-96-1 | MF: | C12H17N3O5S | MW: | 315.35 | EINECS: | 1592732-453-0 | Product Categories: | 1228779-96-1 | Mol File: | 1228779-96-1.mol | |
| 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Chemical Properties |
Melting point | 188 - 191°C | Boiling point | 542.0±60.0 °C(Predicted) | density | 1.412±0.06 g/cm3(Predicted) | storage temp. | 2-8°C(protect from light) | solubility | DMSO (Slightly), Methanol (Slightly) | pka | 9.58±0.60(Predicted) | form | Solid | color | Yellow to Dark Yellow | CAS DataBase Reference | 1228779-96-1 |
| 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Usage And Synthesis |
Uses | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a pharmaceutical intermediate compound used in the preparation of Venetoclax, which is used to treat certain types of chronic lymphocytic leukaemia (CL) or certain types of small lymphocytic lymphoma (SLL). | Uses | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is a reagent used in the synthesis of BTK, PI3K and JAK-2 inhibitors. | Synthesis | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide is prepared by the reaction of 4-Aminomethyltetrahydropyran and 4-Fluoro-3-nitrobenzenesulfonamide. The specific synthesis steps are as follows: 4-Fluoro-3-nitrobenzenesulfonamide (1.0 g, 4.54 mmol), (tetrahydro-2H-pyran-4-yl)methylamine (0.6 g, 4.49 mmol), Triethylamine (1.3 g, 6.81 mmol) was added to 10 ml of tetrahydrofuran solution. After stirring at room temperature for 5 h, the solvent was removed. Add 20ml of methanol to beat, After drying, the product was obtained in an amount of 1.4 g. The yield was 97percent.
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| 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide Preparation Products And Raw materials |
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