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ChemicalBook > Product Catalog >Organic Chemistry >Nitrogen Compounds >1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol

1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol

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Company Name: Shanghai Yingrui Biopharma Co., Ltd.
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Products Intro: Product Name:1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
CAS:685514-01-6
Purity:99% Package:0KG;0USD
Company Name: Shanghai Yingrui Biopharma Co.,Ltd
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Products Intro: Product Name:1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
CAS:685514-01-6
Purity:0.95 Package:25 kilograms per barrel
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Products Intro: Product Name:1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
CAS:685514-01-6
Purity:99% Package:1KG;1USD
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Products Intro: Product Name:1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol
CAS:685514-01-6
Purity:95% Package:100g; 1kg Remarks:LN01354547
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Products Intro: Product Name:1-triisopropylsilylpyrrolo[2,3-b]pyridin-5-ol
CAS:685514-01-6

1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol manufacturers
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Basic information
Product Name:1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
Synonyms:1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-;1-[Tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol;1-triisopropylsilylpyrrolo[2,3-b]pyridin-5-ol;1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-4-sulfonic acid;1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridin-5-ol;1-tri(propan-2-yl)silylpyrrolo[2,3-b]pyridin-5-ol;1-Triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-5-ol;1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol
CAS:685514-01-6
MF:C16H26N2OSi
MW:290.48
EINECS:
Product Categories:
Mol File:685514-01-6.mol
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Structure
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Chemical Properties
Boiling point 341.6±35.0 °C(Predicted)
density 1.03±0.1 g/cm3(Predicted)
pka8.50±0.40(Predicted)
Safety Information
MSDS Information
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Usage And Synthesis
SynthesisAdd 10.8g (34mmol) of (1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 120mL of tetrahydrofuran to a round bottom flask equipped with a magnetic stirrer, an inert gas source and a separating funnel, and stir to dissolve; Add 34mL of 1mol/L sodium hydroxide solution and 4.60g (40.6mmol) of 30% hydrogen peroxide dropwise at 0°C. After the addition, React at 0°C for 1 hour and detect the reaction by TLC. Add 4.8g (20.24mmol) of sodium thiosulfate, adjust to pH=5 with 2mol/L hydrochloric acid, extract with ethyl acetate (2x200mL), combine the organic phases, wash with saturated brine in turn, dry with a sodium sulfate, and reduce Concentrate under pressure. The residue was purified by silica gel column chromatography [eluent: dichloromethane] to obtain 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol 9.4g, yield 95.0%.
1H-Pyrrolo[2,3-b]pyridin-5-ol, 1-[tris(1-methylethyl)silyl]-
1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol Preparation Products And Raw materials
Preparation Products2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid
Tag:1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridin-5-ol(685514-01-6) Related Product Information
2-[(1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoic acid 1-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine ABT-199 Methyl 4-Fluoro-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzoate 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide 4'-chloro-5,5-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carbaldehyde 1H-PYRROLO[2,3-B]PYRIDIN-5-OL