左旋沙丁胺醇
中文名称 | 左旋沙丁胺醇 |
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中文同义词 | 左旋沙丁胺醇;4-[2-(叔丁氨基)-1-羟乙基]-2-(羟甲基)苯酚;左旋沙丁胺醇盐酸盐;4-(2-(叔丁胺基)-1-羟乙基)-2-(羟甲基)苯酚硫酸盐;化合物8-AZABICYCLO[3.2.1]OCTAN-3-ONE |
英文名称 | Salbutamol |
英文同义词 | LEVALBUTEROL;LEVALBUTEROL HCL;(L)-ALBUTEROL;R-SALBUTAMOL HCL;(-)-alpha(sup1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedime;1,3-benzenedimethanol,alpha(sup1)-(((1,1-dimethylethyl)amino)methyl)-4-hydrox;alpha’-diol,alpha(sup1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-alph;r-albuterol |
CAS号 | 34391-04-3 |
分子式 | C13H21NO3 |
分子量 | 239.31 |
EINECS号 | 242-424-0 |
相关类别 | 原料药;医药原料药 |
Mol文件 | 34391-04-3.mol |
结构式 |
左旋沙丁胺醇 性质
沸点 | 433.5±40.0 °C(Predicted) |
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密度 | 1.152±0.06 g/cm3(Predicted) |
酸度系数(pKa) | 9.99±0.31(Predicted) |
InChI | InChI=1/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/s3 |
InChIKey | NDAUXUAQIAJITI-PLAQIDKDNA-N |
SMILES | C1(=CC=C(O)C(CO)=C1)[C@@H](O)CNC(C)(C)C |&1:9,r| |
CAS 数据库 | 34391-04-3(CAS DataBase Reference) |
Levalbuterol (10 μM; 24 hours) induces 11β-HSD1 mRNA expression, however, it does not influence 11β-HSD2 expression in airway epithelial cells.Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line.
RT-PCR
Cell Line: | Murine Club (MTCC) cells |
Concentration: | 10 μM |
Incubation Time: | 24 hours |
Result: | Increased 11β-HSD1 mRNA expression selectively. |
Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE.
Animal Model: | C57BL/6 female mice with a pulmonary allergic model |
Dosage: | 1 mg/kg |
Administration: | Subcutaneous injection; 1 mg/kg; 14 days |
Result: | Decreased pulmonary inflammation after OVA sensitization. |