左旋沙丁胺醇
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- CAS号:
- 34391-04-3
- 英文名:
- Salbutamol
- 英文别名:
- Salbutamol;r-albuterol;LEVALBUTEROL;Levalbutreol;(L)-ALBUTEROL;Levosalbutamol;R-SALBUTAMOL HCL;LEVALBUTEROL HCL;LEVOSALBUTEROLHCL;Levosalbutamol (Levalbuterol)
- 中文名:
- 左旋沙丁胺醇
- 中文别名:
- 左旋沙丁胺醇;左旋沙丁胺醇盐酸盐;4-[2-(叔丁氨基)-1-羟乙基]-2-(羟甲基)苯酚;4-(2-(叔丁胺基)-1-羟乙基)-2-(羟甲基)苯酚硫酸盐;化合物8-AZABICYCLO[3.2.1]OCTAN-3-ONE
- CBNumber:
- CB0275903
- 分子式:
- C13H21NO3
- 分子量:
- 239.31
- MOL File:
- 34391-04-3.mol
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左旋沙丁胺醇化学性质
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沸点:
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433.5±40.0 °C(Predicted)
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密度:
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1.152±0.06 g/cm3(Predicted)
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酸度系数(pKa):
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9.99±0.31(Predicted)
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InChI:
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InChI=1/C13H21NO3/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15/h4-6,12,14-17H,7-8H2,1-3H3/t12-/s3
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InChIKey:
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NDAUXUAQIAJITI-PLAQIDKDNA-N
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SMILES:
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C1(=CC=C(O)C(CO)=C1)[C@@H](O)CNC(C)(C)C |&1:9,r|
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CAS 数据库:
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34391-04-3(CAS DataBase Reference)
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左旋沙丁胺醇性质、用途与生产工艺
Levalbuterol ((R)-Albuterol; (R)-Salbutamol) 是短效 β2-肾上腺素受体 (β2-adrenergic receptor) 激动剂和 Salbutamol 的活性 R 型对映异构体。Levalbuterol 是一种比 Salbutamol 更有效的支气管扩张试剂,可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。
Levalbuterol (10 μM; 24 hours) induces
11β-HSD1
mRNA expression, however, it does not influence
11β-HSD2
expression in airway epithelial cells.Levalbuterol (10 μM; 24 hours) significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line.
RT-PCR
Cell Line:
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Murine Club (MTCC) cells
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Concentration:
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10 μM
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Incubation Time:
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24 hours
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Result:
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Increased
11β-HSD1
mRNA expression selectively.
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Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE.
Animal Model:
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C57BL/6 female mice with a pulmonary allergic model
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Dosage:
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1 mg/kg
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Administration:
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Subcutaneous injection; 1 mg/kg; 14 days
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Result:
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Decreased pulmonary inflammation after OVA sensitization.
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左旋沙丁胺醇
上下游产品信息
上游原料
下游产品
34391-04-3, 左旋沙丁胺醇 相关搜索:
- API
- 医药原料药
- 原料药
- C13H21NO3
- 51022-72-9
- 化合物8-AZABICYCLO[3.2.1]OCTAN-3-ONE
- 4-(2-(叔丁胺基)-1-羟乙基)-2-(羟甲基)苯酚硫酸盐
- 左旋沙丁胺醇盐酸盐
- 4-[2-(叔丁氨基)-1-羟乙基]-2-(羟甲基)苯酚
- 左旋沙丁胺醇
- 34391-04-3
- (+/-) - Albuterol (Levalbuterol)
- 1,3-Benzenedimethanol, α1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (α1R)-
- 2-(Hydroxymethyl)-4-{(1R)-1-hydroxy-2-[(2-methyl-2-propanyl)amino]ethyl}phenol
- Levosalbutamol (Levalbuterol)
- 4-[(1R)-2-(tert-butylamino)-1-hydroxy-ethyl]-2-methylol-phenol
- 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
- 4-[(1R)-2-(tert-butylamino)-1-hydroxy-ethyl]-2-(hydroxymethyl)phenol
- (αR)-α-[(tert-Butylamino)methyl]-4-hydroxy-1,3-benzenedimethanol
- (R)-4-Hydroxy-3-(hydroxymethyl)-α-[[(tert-butyl)amino]methyl]benzyl alcohol
- (R)-1-(4-Hydroxy-3-hydroxymethylphenyl)-2-tert-butylaminoethanol
- (R)-1-(4-Hydroxy-3-hydroxymethylphenyl)-2-(1,1-dimethylethylamino)ethanol
- Salbutamol
- Levalbutreol
- 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol
- 2-(hydroxymethyl)-4-[(1R)-1-hydroxy-2-(tert-butylamino)ethyl]phenol
- m-Xylene-a,a'-diol, a1-[(tert-butylamino)methyl]-4-hydroxy-, (R)-(-)- (8CI)
- Levosalbutamol
- 1,3-Benzenedimethanol, a1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (R)-
- 1,3-Benzenedimethanol, a1-[[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-, (a1R)- (9CI)
- LEVOSALBUTEROLHCL
- 2-(hydroxymethyl)-4-[1-hydroxy-2-(tert-butylamino)ethyl]phenol
- r-albuterol
- alpha’-diol,alpha(sup1)-((tert-butylamino)methyl)-4-hydroxy-m-xylene-alph
- 1,3-benzenedimethanol,alpha(sup1)-(((1,1-dimethylethyl)amino)methyl)-4-hydrox
- (-)-alpha(sup1)-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedime
- R-SALBUTAMOL HCL
- (L)-ALBUTEROL
- LEVALBUTEROL HCL
- LEVALBUTEROL