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| 化学名: | 3-メチル-1H-インダゾール | | 英語化学名: | 3-METHYL-1H-INDAZOLE | | 别名: | 3-METHYL-1H-INDAZOLE;1H-Indazole, 3-methyl-;1-Propanone,1-(3,9-dichlorophenyl)-;Benzenamine,N,N,3,9-tetramethyl- | | CAS番号: | 3176-62-3 | | 分子式: | C8H8N2 | | 分子量: | 132.16 | | EINECS: | 1533716-785-6 | | カテゴリ情報: | Indazole | | Mol File: | 3176-62-3.mol |  |
| 融点 | 113°C | | 沸点 | 234.08°C (rough estimate) | | 比重(密度) | 1.1083 (rough estimate) | | 屈折率 | 1.6013 (estimate) | | 貯蔵温度 | Sealed in dry,Room Temperature | | 酸解離定数(Pka) | 14.39±0.40(Predicted) |
| 主な危険性 | Xn | | Rフレーズ | 22 | | HSコード | 2933998090 |
| | 3-メチル-1H-インダゾール Usage And Synthesis |
| 説明 | 3-Methyl-1H-indazole is a heterocyclic alkyl compound containing nitrogen and three methyl groups. It is used as an intermediate in the synthesis of other compounds. It has been shown to have anti-inflammatory properties in vitro. It also inhibits neutrophil chemotaxis and may be used to treat inflammatory diseases such as trigeminal neuralgia or heart disease. 3-Methyl-1H-indazole has also been shown to inhibit histamine H3 receptor activity, which may account for its effects on eye diseases and bladder cancer. | | 使用 | 3-Methyl-1H-indazole is an intermediate compound. It can be used as an organic synthesis reagent for the preparation of 3-methyl-1H-indazol-5-amine and 3-methyl-5-nitro-1H-indazole compounds. In addition, the 3-Methyl-1H-indazole derivatives (1a-1d and 2a-2d) have antimicrobial effects, both having antibacterial activity against Bacillus subtilis and Escherichia coli[1]. | | Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 25, p. 1817, 1988 DOI: 10.1002/jhet.5570250641
Synthesis, p. 982, 1984 | | 参考文献 | [1] FARRUKH SHAIKH. Synthesis and evaluation of antibacterial activity of novel 3-methyl-1H-indazole derivatives[J]. Intelligent Pharmacy, 2024. DOI:10.1016/j.ipha.2023.09.003. |
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