2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
| 中文名称 | 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 |
|---|---|
| 中文同义词 | 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚;RSK抑制剂(LJH685);化合物LJH685;2,6-二氟-4-(4-(4-(4-甲基哌嗪-1-基)苯基)吡啶-3-基)苯酚;化合物LJH685,10 MM DMSO 溶液 |
| 英文名称 | 1627710-50-2 |
| 英文同义词 | LJH685;Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-;CS-2182;LJH-685;LJH 685;LJH685;LJH685(LJH-685);2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol;LJH685,S6K,LJH-685,Apoptosis,inhibit,Ribosomal S6 Kinase (RSK),LJH 685,Inhibitor;LJH685, 10 mM in DMSO |
| CAS号 | 1627710-50-2 |
| 分子式 | C22H21F2N3O |
| 分子量 | 381.42 |
| EINECS号 | |
| 相关类别 | 抑制剂;细胞生物学试剂 |
| Mol文件 | 1627710-50-2.mol |
| 结构式 | ![2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 结构式](CAS/20200611/GIF/1627710-50-2.gif) |
2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 性质
| 沸点 | 481.1±45.0 °C(Predicted) |
|---|---|
| 密度 | 1.257±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 5.86±0.25(Predicted) |
| 颜色 | 白色至米白色 |
| InChI | 1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 |
| InChIKey | IKUFKDGKRLMXEX-UHFFFAOYSA-N |
| SMILES | Fc1c(c(cc(c1)c2cnccc2c3ccc(cc3)N4CCN(CC4)C)F)O |
LJH685 是一种有效的选择性，ATP-竞争性的 RSK 抑制剂, 抑制 RSK1/2/3 生物活性, IC50 为 6、5、4 nM。
IC50: 6 nM (RSK1), 5 nM (RSK1), 4 nM (RSK1)
LJH685 (0.01-100 μM; 72 hours) efficiently inhibits the growth of MDA-MB-231 and H358 cells in soft agar with EC 50 s of 0.73 and 0.79 μM, respectively. LJH685 (0.1-10 μM; 4 hours) efficiently reduces phosphorylation of YB1 at submicromolar concentrations and causes nearly complete inhibition at higher concentrations.
Cell Proliferation Assay
| Cell Line: | MDA-MB-231, H358 cells |
| Concentration: | 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time: | 72 hours |
| Result: | The growth in soft agar was efficiently inhibited with EC 50 values of 0.73 and 0.79 μM in MDA-MB-231 and H358, respectively. |
Western Blot Analysis
| Cell Line: | MDA-MB-231, H358 cells |
| Concentration: | 0.1, 0.3, 1, 3, 10 μM |
| Incubation Time: | 4 hours |
| Result: | Efficiently reduced phosphorylation of YB1 at submicromolar concentrations and caused nearly complete inhibition at higher concentrations. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 海关编码 | 2933998090 |
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-19712 | 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 LJH685 | 1627710-50-2 | 1 mg | 431元 |
| 2026/09/15 | HY-19712 | 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 LJH685 | 1627710-50-2 | 5mg | 800元 |