- C-DIM12
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- $1.00 / 100g
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2019-12-23
- CAS:178946-89-9
- Min. Order: 100g
- Purity: 99%
- Supply Ability: G/KG/T
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| | C-DIM12 Basic information |
| Product Name: | C-DIM12 | | Synonyms: | C-DIM12;C-DIM12(1,1-bis (3'-indolyl)-1-(p-chlorophenyl) methane);C-DIMI2;3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole;C-DIM12, 178946-89-9;C-DIM12 (C-DIM-12;CS-2311;C-DIM12, >98% | | CAS: | 178946-89-9 | | MF: | C23H17ClN2 | | MW: | 356.85 | | EINECS: | | | Product Categories: | | | Mol File: | 178946-89-9.mol |  |
| | C-DIM12 Chemical Properties |
| Melting point | 76-77 °C | | Boiling point | 585.6±45.0 °C(Predicted) | | density | 1.324±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml) | | form | solid | | pka | 16.40±0.30(Predicted) | | color | Orange | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| | C-DIM12 Usage And Synthesis |
| Description | C-DIM12 is a para-phenyl-substituted diindolylmethane (C-DIM) that is an orally bioavailable activator of nuclear receptor-related protein 1 (Nurr1/NR4A2). It is selective for Nurr1, not activating Nur77, neuron-derived orphan receptor 1 (Nor1), or the retinoid X receptor (RXR) in parallel luciferase assays. C-DIM12 (2.5-10 μM) inhibits proliferation of Ku7 and 253J B-V bladder cancer cells in a dose-dependent manner and induces apoptosis of KU7 cells in a Nurr1-dependent manner. In an orthotopic nude mouse model, C-DIM12 suppresses bladder cancer cell growth by 44 and 59% at doses of 12.5 and 25 mg/kg, respectively. C-DIM12 has neuroprotective properties, preventing dopaminergic cell loss and reducing the expression of NF-κB in the substantia nigra pars compacta in an MPTP mouse model of Parkinson’s disease. It also has analgesic and anti-inflammatory activity in the tail immersion and carrageenan paw edema assays at a dose of 100 mg/kg, without causing ulcers in rats. | | storage | Store at -20°C | | References | 1) Inamoto et al. (2008), 1,1-Bis(3’-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth; Mol Cancer Ther., 7 3825
2) Li et al. (2012), Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3’-indoyl)-1-(aromatic)methane analogs in pancreatic cancer cells; Biochem. Pharmacol., 83 1445
3) De Miranda et al. (2015), The Nurr1 Activator 1,1-Bis(3’-Indolyl)-1-(p-chlorophenyl)Methane blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor kB; Mol. Pharmacol., 87 1021
4) De Miranda et al. (2013), Neuroprotective efficacy and pharmokinetic behavior of novel anti-inflammatory para phenyl substituted diindolylmethanes ina a mouse model of Parkinson’s disease; J. Pharmacol. Exp. Ther., 345 125 |
| | C-DIM12 Preparation Products And Raw materials |
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