那他珠单抗
| 中文名称 | 那他珠单抗 |
|---|---|
| 中文同义词 | NATALIZUMAB ( 那他珠单抗 ) |
| 英文名称 | Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer |
| 英文同义词 | Immunoglobulin G4,anti-(human integrin R4) (human-mouse monoclonal AN100226 c4-chain),disulfide with human-mouse monoclonal AN100226 light chain,dimer;Natalizumab-Tysabri;Research Grade Natalizumab(DHC98801);inhibit,Inhibitor,Natalizumab,Integrin |
| CAS号 | 189261-10-7 |
| 分子式 | C40H55N7O11S |
| 分子量 | 841.97 |
| EINECS号 | |
| 相关类别 | 化学试剂 |
| Mol文件 | 189261-10-7.mol |
| 结构式 |  |
那他珠单抗 性质
| 储存条件 | Store at 4°C, do not freeze |
|---|
Natalizumab, a recombinant, humanized antibody, binds to α4β1-integrin and blocks its interaction with VCAM-1. As a result, leukocyte migration into brain tissue is inhibited, reducing inflammation and preventing the formation of lesions. Natalizumab may also inhibit ongoing central nervous system (CNS) inflammation, mediated by leukocytes already present in the CNS, by interrupting the interactions between α4-integrin-expressing leukocytes and extracellular matrix proteins such as fibronectin and osteopontin.
Natalizumab binds rapidly and with high affinity to α4-integrin. Maximal binding (≥80% saturation), measured in vitro on isolated lymphocyte membranes, occurred 24 hours after intravenous (IV) doses of natalizumab 1 mg/kg to 6 mg/kg.