氯谷胺
| 中文名称 | 氯谷胺 |
|---|---|
| 中文同义词 | 氯谷胺;氯谷胺, >98%;LOXIGLUMIDE,CCK1拮抗剂;4-(3,4-二氯苯甲酰胺基)-5-((3-甲氧基丙基)(戊基)氨基)-5-氧代戊酸;氯谷胺,10 MM DMSO 溶液;【进口原装】氯谷胺107097-80-3;【进口原装】氯谷胺107097-80-3 |
| 英文名称 | LOXIGLUMIDE |
| 英文同义词 | 4-[(3,4-dichlorobenzoyl)amino]-5-[3-methoxypropyl(pentyl)amino]-5-oxopentanoic acid;4-[(3,4-dichlorophenyl)carbonylamino]-5-[3-methoxypropyl(pentyl)amino]-5-oxo-pentanoic acid;5-[amyl(3-methoxypropyl)amino]-4-[(3,4-dichlorobenzoyl)amino]-5-keto-valeric acid;LoxigluMide (CR1505);LOXIGLUMIDE;(+-)-4-((3,4-dichlorobenzoyl)amino)-5-((3-methoxypropyl)pentylamino)-5-oxope;(+-)--5-oxo;anoicacid |
| CAS号 | 107097-80-3 |
| 分子式 | C21H30Cl2N2O5 |
| 分子量 | 461.38 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂，天然产物;小分子抑制剂;Inhibitors |
| Mol文件 | 107097-80-3.mol |
| 结构式 |  |
氯谷胺 性质
| 熔点 | 113-115℃ |
|---|---|
| 沸点 | 632.2±55.0 °C(Predicted) |
| 密度 | 1.233±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 酸度系数(pKa) | pKa ~5(at 25℃) |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| InChI | 1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27) |
| InChIKey | QNQZBKQEIFTHFZ-UHFFFAOYSA-N |
| SMILES | CCCCCN(CCCOC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1 |
| CAS 数据库 | 107097-80-3 |
Loxiglumide 是缩胆囊素 (CCK-1) 受体拮抗剂。
CCK-1 receptor
The effects of pancreatic rest by oral administration of CCK-1 receptor antagonist Loxiglumide and pancreas stimulation are investigated via endogenous CCK release induced by po protease inhibitor camostat on the recovery of pancreatic secretory function, and biochemical and histological changes of the pancreas after acute hemorrhagic pancreatitis. Oral administration of CCK-1 receptor antagonist Loxiglumide with a dose of 50 mg/kg body weight inhibits pancreatic exocrine secretion for more than 12 h. Thus, every 12-h administration of Loxiglumide might have completely blocks the effect of endogenously released CCK on the pancreas (pancreatic rest).
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-B2154 | 氯谷胺 Loxiglumide | 107097-80-3 | 5 mg | 360元 |
| 2025/12/22 | HY-B2154 | 氯谷胺 Loxiglumide | 107097-80-3 | 10mg | 660元 |