| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
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PF04191834 manufacturers
- PF-4191834
-
- $48.00
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2026-07-14
- CAS:1029317-21-2
- Purity: 99.85%
- Supply Ability: 10g
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| | PF04191834 Basic information |
| Product Name: | PF04191834 | | Synonyms: | PF04191834;2H-Pyran-4-carboxamide, tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-;PF-4191834 >=98% (HPLC);PF4191834,Lipoxygenase,PF 4191834,inhibit,LOX,PF 04191834,PF-4191834,PF04191834,Inhibitor;PF-4191834, 10 mM in DMSO;4-(3-((4-(1-Methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide;PF-4191834 | | CAS: | 1029317-21-2 | | MF: | C22H23N3O2S | | MW: | 393.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1029317-21-2.mol |  |
| | PF04191834 Chemical Properties |
| Melting point | 173 °C | | Boiling point | 663.0±55.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 15.78±0.20(Predicted) | | color | White to yellow | | InChI | 1S/C22H23N3O2S/c1-25-20(9-12-24-25)16-5-7-18(8-6-16)28-19-4-2-3-17(15-19)22(21(23)26)10-13-27-14-11-22/h2-9,12,15H,10-11,13-14H2,1H3,(H2,23,26) | | InChIKey | DVNQWYLVSNPCJZ-UHFFFAOYSA-N | | SMILES | NC(C1(CCOCC1)C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | PF04191834 Usage And Synthesis |
| Uses | PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM), displays ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain[1]. | | Biological Activity | PF-4191834 (PF-04191834) is an orally active, non-iron-chelating, non-redox 5-lipoxygenase (5-LOX) inhibitor (IC50=229 nM), 5-LOX is about 300 times more selective than 12-LOX and 15-LOX, has no activity against cyclooxygenase, and is effective against inflammation and pain. | | in vitro | PF-4191834 (PF-04191834) inhibits the synthesis of the 5-LOX products 5-HETE, 5-oxo-ETE, LTB4, and LTE4 with estimated IC 50 values between 100 and 190 nM and do not inhibit significantly the COX-1/2 enzymes or the 12- or 15-LOX enzymes at concentrations up to 30 μM. PF-4191834 (PF-04191834) exerts a concentration-dependent inhibition of human 5-LOX, with an IC 50 value of 130 nM and an IC 80 value of 370 nM. | | target | | | IC 50 | 5-LOX | | References | [1] Masferrer JL, et al. Pharmacology of PF-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301. DOI:10.1124/jpet.110.166967 |
| | PF04191834 Preparation Products And Raw materials |
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