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| | 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER Basic information |
| Product Name: | 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER | | Synonyms: | Benzoic acid, 4-(2-broMoacetyl)-, Methyl ester;Methyl 4-(BroMoacetyl)benzoate;Methyl p-(BroMoacetyl)benzoate;α-BroMo-4-(carboMethoxy)acetophenone;ω-BroMoacetophenone-4-carboxylic Αcid Methyl Ester;4-(Methoxycarbonyl)phenacyl bromide, 2-Bromo-4'-(methoxycarbonyl)acetophenone;4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER;Fs005025 | | CAS: | 56893-25-5 | | MF: | C10H9BrO3 | | MW: | 257.08 | | EINECS: | | | Product Categories: | Aromatics;Intermediates | | Mol File: | 56893-25-5.mol |  |
| | 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER Chemical Properties |
| Boiling point | 342.8±22.0 °C(Predicted) | | density | 1.494±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | color | Beige |
| | 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER Usage And Synthesis |
| Uses | A phenacyl bromide | | Synthesis | General procedure for the synthesis of methyl 4-(2-bromoacetyl)benzoate from methyl 4-acetylbenzoate: Bromine (2.71 mL, 52.5 mmol) was added dropwise to a solution of methyl 4-acetylbenzoate (8.91 g, 50.0 mmol) in acetic acid (80 mL). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and filtered to collect the solid. The resulting precipitate was washed with a 1:1 mixed methanol-water solution and subsequently dried to afford methyl 4-(2-bromoacetyl)benzoate (10.6 g, 82% yield) as a brown solid. The product was characterized by 1H NMR (400 MHz, CDCl3) with chemical shifts of δ 8.19-8.12 (m, 2H), 8.04 (d, J = 8.5 Hz, 2H), 4.47 (s, 2H), 3.96 (s, 3H). | | References | [1] Journal of the American Chemical Society, 2000, vol. 122, # 39, p. 9361 - 9366
[2] Patent: WO2006/78698, 2006, A1. Location in patent: Page/Page column 64
[3] Patent: US2012/196869, 2012, A1. Location in patent: Paragraph 0467; 0468; 0469
[4] Inorganic Chemistry, 2018, vol. 57, # 1, p. 120 - 128
[5] Patent: WO2008/33745, 2008, A2. Location in patent: Page/Page column 70-71 |
| | 4-(2-BROMO-ACETYL)-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials |
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