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| 化学名: | 3,3'-イミノジプロピオニトリル | | 英語化学名: | 3,3'-IMINODIPROPIONITRILE | | 别名: | TIMTEC-BB SBB007920;.beta.,.beta.’-Iminodipropionitrile;2,2’-dicyano-diethylamin;2341 I.S.;2341i.s.;2-cyano-n-(2-cyanoethyl)-ethanamin;3,3'-Iminodipropanenitrile;BBCE | | CAS番号: | 111-94-4 | | 分子式: | C6H9N3 | | 分子量: | 123.16 | | EINECS: | 203-922-3 | | カテゴリ情報: | Organics | | Mol File: | 111-94-4.mol |  |
| 融点 | -6 °C | | 沸点 | 205 °C25 mm Hg(lit.) | | 比重(密度) | 1.02 g/mL at 25 °C(lit.) | | 屈折率 | n20/D 1.47(lit.) | | 闪点 | >230 °F | | 貯蔵温度 | 2-8°C | | 酸解離定数(Pka) | 6.13±0.19(Predicted) | | 外見 | clear liquid | | 色 | Colorless to Light yellow to Light orange | | 水溶解度 | Soluble in water. | | 安定性： | Stable, but moisture sensitive. Reaction with moisture may lead to a build up of pressure in sealed bottles. Combustible. Incompatible with strong oxidizing agents. | | CAS データベース | 111-94-4(CAS DataBase Reference) | | EPAの化学物質情報 | 3,3'-Iminobispropanenitrile (111-94-4) |
| 主な危険性 | Xi | | Rフレーズ | 36/37/38 | | Sフレーズ | 26 | | RIDADR | UN 3334 | | WGK Germany | 2 | | RTECS 番号 | UG2975000 | | TSCA | Yes | | HSコード | 29269095 | | 有毒物質データの | 111-94-4(Hazardous Substances Data) | | 毒性 | A neurotoxic synthetic
nitrile that causes proximal axonopathies in the spinal cord and
brain stem. The proximal axonal swellings are due to interruption
of slow axonal transport, resulting in a large accumulation
of neurofilaments. Secondary to these effects is a progressive
atrophy of the distal axon, secondary demyelination, and gliosis.
The slow axonal transport defect appears to be selective,
as little evidence for perturbations in fast axonal transport have
been reported. Behaviorally, IDPN induces hyperactivity, a
“waltzing syndrome,” circling and head-rolling in mice and
rats. IDPN intoxication has been advanced as a model for
certain motor neuron degenerative diseases such as amyotropic
lateral sclerosis (ALS) and hereditary canine spinal muscular
atrophy (HCSMA). |
| | 3,3'-イミノジプロピオニトリル Usage And Synthesis |
| 外観 | 無色～黄褐色, 澄明の液体 | | 溶解性 | 水、エタノール及びアセトンに混和する。水に極めて溶けやすい。 | | 用途 | 生化学研究用試薬。有機合成原料(繊維染色剤原料)。 | | 化学的特性 | colourless liquid | | 使用 | Bis(2-cyanoethyl)amine is used as pharmaceutical intermediates. | | 一般的な説明 | Clear colorless liquid. | | 空気と水の反応 | Water soluble. Moisture sensitive. Some 18-month old bottles of 3,3'-IMINODIPROPIONITRILE exploded, probably owing to slow hydrolysis and buildup of pressure. Solutions in water are unstable above pH 4. . | | 反応プロフィール | Nitriles, such as 3,3'-IMINODIPROPIONITRILE, may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids. | | 火災危険 | 3,3'-IMINODIPROPIONITRILE is combustible. |
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