| Company Name: |
Beijing HwrkChemical Technology Co., Ltd
|
| Tel: |
010-89508211 18501085097 |
| Email: |
sales.bj@hwrkchemical.com |
| Products Intro: |
Product Name:3-aza-13-azoniapentacyclo[11.7.0.02,10.04,9.014,19]icosa-1(13),2(10),4,6,8,11,14,16,18-nonaen-20-one;chloride
CAS:114719-57-2
Purity:98%(HPLC) Package:1g/5g/100g Remarks:HWG57462
|
| Company Name: |
BeiJing Hwrk Chemicals Limted
|
| Tel: |
0757-86329057 18934348241 |
| Email: |
sales4.gd@hwrkchemical.com |
| Products Intro: |
Product Name:12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride
CAS:114719-57-2
Purity:98%(HPLC) Package:1g
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:Fascaplysin chloride
CAS:114719-57-2
Purity:≥95% Remarks:Fascaplysin is a cell-permeable red pigment that acts as an inhibitor of cyclin D kinase 4/cyclin D1 (IC50 = 0.35 μM). It is significantly less selective for Cdk6/cyclin D1 (IC50 = 3.4 μM) and does no
|
|
| | FASCAPLYSIN CHLORIDE Basic information |
| Product Name: | FASCAPLYSIN CHLORIDE | | Synonyms: | fascaplysine;Fascaplysin chloride hydrate;Fascaplysine hydrate, Pyrido[1,2-a:3,4-b]diindol-5-ium,12,13-dihydro-13-oxo-, chloride (9CI);FASCAPLYSIN CHLORIDE;Fascaplysin (chloride)|CDK4 inhibitor;12,13-dihydro-13-oxo-pyrido[1,2-a:3,4-b']diindol-5-ium,monochloride;Pyrido[1,2-a:3,4-b']diindol-5-ium, 12,13-dihydro-13-oxo-, chloride;Fascaplysin, ATP-competitve CDK4 inhibitor | | CAS: | 114719-57-2 | | MF: | C18H11ClN2O | | MW: | 306.74574 | | EINECS: | | | Product Categories: | | | Mol File: | 114719-57-2.mol |  |
| | FASCAPLYSIN CHLORIDE Chemical Properties |
| storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 20 mg/ml) or in Water (up to 2 mg/ml) | | form | solid | | color | Dark red-brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months. |
| | FASCAPLYSIN CHLORIDE Usage And Synthesis |
| Description | Fascaplysin (114719-57-2) is a novel marine natural product isolated from?Thorectandra sp.1?A potent and selective inhibitor of cyclin dependent kinase 4/cyclin D1 (IC50?= 0.35 μM) and is less selective for Cdk6/D1 (IC50?= 3.4 μM). Displays antiangiogenic acitivity.2?Fascaplysin displays high cytotoxic activity against small cell lung cancer cell lines acting via multiple mechanisms including topoisomerase I, DNA integrity and ROS.3 | | Uses | Fascaplysin Chloride is a selective CDK4/cyclin D1 inhibitor. Downregulates the PI3K pathway in cancer cells and also has an effect on erythrocytes and thrombosis. | | in vivo | Fascaplysin suppresses the growth of S180 cell-implanted tumors in vivo[2] | | IC 50 | CDK4 | | References | 1) Soni?et al. (2000),?Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product; Biochem. Biophys. Res. Commun.,?275?877
2) Lin?et al. (2007),?Fascaplysin, a selective CDK4 inhibitor, exhibit anti-angiogenic activity in vitro and in vivo; Cancer Chemother. Pharmacol.,?59?439
3) Hamilton?et al. (2014),?Cytotoxic effects of fascaplysin against small cell lung cancer cell lines; Mar. Drugs,?12?1377 |
| | FASCAPLYSIN CHLORIDE Preparation Products And Raw materials |
|