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Product Name:(-)-[3R,4S]-ChroManol 293B;N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-diMethyl-2H-1-benzopyran-4-yl]-N-MethylethanesulfonaMide
CAS:163163-24-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | (-)-[3R,4S]-CHROMANOL 293B Basic information |
| Product Name: | (-)-[3R,4S]-CHROMANOL 293B | | Synonyms: | N-[(3R,4S)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-METHYLETHANESULFONAMIDE;Chromanol 293B [3R,4S]-(-)-;Ethanesulfonamide, N-[(3R,4S)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-;(-)-[3R,4S]-Chromano;(-)-[3R;(-)-[3R,4S]-Chromanol 293B;4S]-Chromanol 293B;(-)-Chromanol 293B | | CAS: | 163163-24-4 | | MF: | C15H20N2O4S | | MW: | 324.4 | | EINECS: | | | Product Categories: | Potassium channel | | Mol File: | 163163-24-4.mol | ![(-)-[3R,4S]-CHROMANOL 293B Structure](CAS/GIF/163163-24-4.gif) |
| | (-)-[3R,4S]-CHROMANOL 293B Chemical Properties |
| Melting point | 192 °C | | Boiling point | 474.1±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | DMSO: 18 mg/mL | | form | solid | | pka | 12.96±0.60(Predicted) | | color | white |
| | (-)-[3R,4S]-CHROMANOL 293B Usage And Synthesis |
| Uses | (-)-Chromanol 293B is a potent and selective inhibitor of the slow component of delayed rectifier K+ current (IKs). (-)-Chromanol 293B can be used for the research of antiarrhythmic[1]. | | Definition | ChEBI: Chromanol 293B is a 1-benzopyran. | | Biological Activity | Enantiomer that selectively inhibits the slow component of delayed rectifier K + current (I Ks ). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC 50 values are 1.36 and 9.6 μ M respectively). Has negligible inhibitory action at hERG channels (IC 50 > 30 μ M). | | storage | Room temperature | | References | [1] Yang IC, et al. Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther. 2000;294(3):955-962. PMID:10945846 |
| | (-)-[3R,4S]-CHROMANOL 293B Preparation Products And Raw materials |
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