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| | 9,10-ジヒドロ-3-ヒドロキシ-1-メトキシ-9,10-ジオキソ-2-アントラセンカルボアルデヒド 製品概要 |
| 化学名: | 9,10-ジヒドロ-3-ヒドロキシ-1-メトキシ-9,10-ジオキソ-2-アントラセンカルボアルデヒド | | 英語化学名: | DAMNACANTHAL | | 别名: | DAMNACANTHAL;DAMNACANTAL;1-Methoxy-2-formyl-3-hydroxy-9,10-anthraquinone;1-Methoxy-3-hydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde;3-HYDROXY-1-METHOXYANTHRAQUINONE-2-ALDEHYDE;1-Methoxy-3-hydroxy-9,10-dioxoanthracene-2-carbaldehyde;9,10-Dihydro-3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarbaldehyde;3-hydroxy-1-methoxy-9,10-dioxo-anthracene-2-carbaldehyde | | CAS番号: | 477-84-9 | | 分子式: | C16H10O5 | | 分子量: | 282.25 | | EINECS: | | | カテゴリ情報: | | | Mol File: | 477-84-9.mol |  |
| | 9,10-ジヒドロ-3-ヒドロキシ-1-メトキシ-9,10-ジオキソ-2-アントラセンカルボアルデヒド 物理性質 |
| 融点 | 218～219℃ | | 沸点 | 531.9±50.0 °C(Predicted) | | 比重(密度) | 1.461±0.06 g/cm3(Predicted) | | 貯蔵温度 | -20°C | | 溶解性 | Soluble in DMSO (up to 7 mg/ml) | | 酸解離定数(Pka) | 5.26±0.20(Predicted) | | 外見 | Pale orange solid. | | 色 | Yellow | | 安定性： | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| | 9,10-ジヒドロ-3-ヒドロキシ-1-メトキシ-9,10-ジオキソ-2-アントラセンカルボアルデヒド Usage And Synthesis |
| 説明 | Damnacanthal (477-84-9) is a potent inhibitor of p56lck?tyrosine kinase activity (IC50?= 17 nM for inhibition of autophosphorylation). Displays 7- to 20-fold selectivity over p59fyn?and p60src?tyrosine kinases and > 40-fold to 100-fold selectivity over other kinases.1?Mobilizes intracellular Ca2+?in dermal fibroblasts.2?Inhibits LIM-kinase, impairing cell migration and invasion.3?A potent inhibitor of angiogenesis.4?Inhibits mast cell activation.5 | | 使用 | Damnacanthal-induced anti-inflammation is associated with inhibition of NF-κB activity. Damnacanthal is used in the treatment of inflammatory-related diseases. | | 定義 | ChEBI: 3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde is a monohydroxyanthraquinone and an aldehyde. | | target | Syk | Akt | IL Receptor | TNF-α | Caspase | NF-kB | p53 | p21 | p38MAPK | Bcl-2/Bax | Histamine Receptor | | 参考文献 | 1) Faltynek?et al.?(1995),?Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity; Biochemistry,?34?12404
2) Aoki?et al.?(2000),?Mechanism of damnacanthal-induced ;Ca(2+)](i) elevation in human dermal fibroblasts; Eur. J. Pharmacol.,?387?119
3) Ohashi?et al.?(2014),?Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion; Mol. Biol. Cell,?25?828
4) Garcia-Vilas?et al.?(2017),?The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects; Cancer Letters,?385?1
5) Garcia-Vilas?et al.?(2015),?Damnacanthal inhibits IgE receptor-mediated activation of mast cells; Mol. Immunol.,?65?86 |
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