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ChemicalBook Optimization Suppliers |
| 名前: |
ACROBiosystems Gold |
| 電話番号: |
18514007688 |
| 電子メール: |
jiaxin.zhao@acrobiosystems.com |
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| 融点 | 269-271 °C (dec.)(lit.) | | 沸点 | 355.49°C (rough estimate) | | 比重(密度) | 1.2639 (rough estimate) | | 屈折率 | 1.7610 (estimate) | | 闪点 | 269-271°C | | 貯蔵温度 | -70°C | | 溶解性 | H2O: soluble | | 外見 | crystalline | | 酸解離定数(Pka) | pKa1 2.7; pKa2 9.9(at 25℃) | | 色 | white | | 水溶解度 | Soluble in water (<1 mg/ml) at 25°C, Acetic acid (49.00-51.00 mg/ml), DMSO (43 mg/ml) at 25°C, ethanol (<1 mg/ml) at 25°C, 0.1 N Sodium hydroxide (1% w/v), methanol (slightly), and dilute aqueous hydrochloric acid or sodium hydroxide (freely). | | Decomposition | 269-271 ºC | | Merck | 14,5311 | | BRN | 21703 | | InChIKey | QANMHLXAZMSUEX-UHFFFAOYSA-N | | LogP | 1.200 (est) | | CAS データベース | 525-79-1(CAS DataBase Reference) | | NISTの化学物質情報 | Kinetin(525-79-1) | | EPAの化学物質情報 | Kinetin (525-79-1) |
| 外観 | 白色～わずかにうすい褐色, 結晶～粉末又は塊 | | 性質 | 6-furfurylaminopurine．C10H9N5O(215.24)．カイネチンは，DNAの熱分解物から単離されたサイトカイニンの一種．融点266～267 ℃(封管中)．220 ℃ で昇華する．pK1 2.7±0.2，pK2 9.9±0.2(水·エタノール1：1)．λmax 268 nm(エタノール)．水，エタノールにやや可溶．森北出版「化学辞典（第2版） | | 定義 | 本品は、次の化学式で表される複素環式化合物である。 | | 溶解性 | 希酸, 希アルカリに易溶、水にほとんど不溶。エタノールに極めて難溶。エタノールに極めて溶けにくく、水にほとんど溶けない。 | | 用途 | 植物生長調節剤。 | | 作用 | 化学式はC1(/0)H9N5O。6−フルフリルアミノプリン。カイネチンは，植物ホルモンの一種。タバコやニンジンの培養細胞の分裂や分化を促進する物質として，1955年にF.スクーグらがDNAの古くなった分解物から発見。天然の植物からは，見出されていない。カイネチンは，植物の細胞分裂促進作用がある．植物細胞の分裂および茎葉への分化の促進，根成長の阻止，側芽形成や葉緑素合成の促進，休眠解除，老化阻止などの作用を示す。天然に存在する植物ホルモンで，同様の作用をもつ物質はサイトカイニンと総称される。 | | 化粧品の成分用途 | 皮膚コンディショニング剤 | | 説明 | Kinetin (or Vivakin) was introduced as Kinerase in the US as a new
ingredient for the treatment of age related photodamage of skin. This 6-
furfurylaminopurine is a synthetic cytokinin, a family of plant growth factors, and
was shown to be a highly potent growth factor. In vitro, it was able to delay or
prevent the onset of age-related changes in skin cells without affecting cellular
lifespan. In a double-blind clinical trial, Kinetin (0.005%) partially reversed the
clinical signs of photodamaged skin and demonstrated a good safety profile.
It could have potential in psoriasis as well as in other proliferative skin disorders. | | 説明 | Kinetin is a cytokinin plant growth regulator with diverse biological activities. Kinetin (0.23 μM) increases p34cdc2-like histone H1 kinase activity, the number of cells in mitosis, and total cell number in arrested N. plumbaginifolia cells. It increases GSH levels and activity of glutathione peroxidase and glutathione reductase, but reduces thiobarbituric acid reactive substances (TBARS) levels, in human skin fibroblasts when used at a concentration of 10 μM. Kinetin (40 μM) reduces age-related enlargement, multinucleation, and accumulation of cellular debris in human mammary skin fibroblasts without affecting proliferative lifespan. | | 化学的特性 | White Solid | | Originator | Senetek (UK) | | 使用 | Kinetin acts as plant growth accelerator, auxin, plant growth regulator, plant cell division promotor. It also acts as cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures. | | 使用 | A cell division factor found in various plant parts and in yeast. A plant growth regulator. Augments growth of microbial cultures | | 使用 | Plant growth regulator. To augment growth of microbial cultures: BE 632589 (1963 to Hoechst). | | 定義 | ChEBI: Kinetin is a member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group. It has a role as a geroprotector and a cytokinin. It is a member of furans and a member of 6-aminopurines. | | brand name | Kinerase | | Synthesis Reference(s) | The Journal of Organic Chemistry, 21, p. 1276, 1956 DOI: 10.1021/jo01117a016 | | 一般的な説明 | Kinetin is an artificial?cytokinin, obtained from herring sperm. It is named due to its ability to stimulate cell division. | | Biochem/physiol Actions | FAPα has in vitro dipeptidyl peptidase activity and collagenolytic activity. It cleaves N-terminal dipeptides from polypeptides and can degrade gelatin and type I collagen. It has also been reported that FAPa has a tumor suppressor activity. | | 純化方法 | It forms platelets from EtOH and sublimes at 220o, but is best done at lower temperatures in a good vacuum. It has been extracted from neutral aqueous solutions with Et2O. [Miller et al J Am Chem Soc 78 1375 1956, Bullock et al. J Am Chem Soc 78 3693 1956, Beilstein 26 III/IV 3586.] |
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