153437-55-9
| 中文名称 | 153437-55-9 |
|---|---|
| 中文同义词 | WHI-P180盐酸盐;化合物 WHI-P180 HYDROCHLORIDE |
| 英文名称 | 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL |
| 英文同义词 | WHI-P180, HYDROCHLORIDE;4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL;WHI-P180 HCl;Janex 3 hydrochloride;4-[(3-hydroxyphenyl)amino]-6,7-dimethoxy-1-quinazolinium chloride;4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL |
| CAS号 | 153437-55-9 |
| 分子式 | C16H16ClN3O3 |
| 分子量 | 333.76954 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |  |
153437-55-9 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
WHI-P180 (Janex 3)是多种激酶抑制剂；抑制 RET，KDR 和 EGFR 的IC50 值分别为5 nM，66 nM 和4 μM。
|
EGFR 4 μM (IC 50 ) |
KDR 66 nM (IC 50 ) |
RET 5 nM (IC 50 ) |
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.