(+/-)-BLEBBISTATIN
| 中文名称 | (+/-)-BLEBBISTATIN |
|---|---|
| 中文同义词 | (±)-布莱比他汀;(±)-BLEBBISTATIN,抑制剂 |
| 英文名称 | (+/-)-BLEBBISTATIN |
| 英文同义词 | (R)-(+)-BLEBBISTATIN;(3AS)-(-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE;(+/-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE;(+/-)-1,2,3,3A-TETRAHYDRO-3A-HYDROXY-6-METHYL-1-PHENYL-4H-PYRROLO[2,3-B]QUINOLIN-4-ONE;(+/-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one;1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one;(3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one;(3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-β]quinolin-4-one |
| CAS号 | 674289-55-5 |
| 分子式 | C18H16N2O2 |
| 分子量 | 292.33 |
| EINECS号 | |
| 相关类别 | 化工;Caspases/Apoptosis;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;All Inhibitors |
| Mol文件 | 674289-55-5.mol |
| 结构式 |  |
(+/-)-BLEBBISTATIN 性质
| 熔点 | 210-212°C |
|---|---|
| 沸点 | 507.3±60.0 °C(Predicted) |
| 密度 | 1.31±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 可溶于氯仿（少量）、二氯甲烷、DMSO、乙酸乙酯、甲醇 |
| 形态 | 亮黄色固体。 |
| 酸度系数(pKa) | 11.15±0.20(Predicted) |
| 颜色 | 粘黄色 |
| CAS 数据库 | 674289-55-5 |
Non-muscle myosin II (NMII)
The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro.
Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model.
| Animal Model: | New Zealand white rabbits (16-20 weeks; 3-3.5 kg) |
| Dosage: | 0.05 mL; 20 μM |
| Administration: | Intracameral injection; daily; for 6 days |
| Result: | Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer. |
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM.
安全信息
| 危险品标志 | Xn |
|---|---|
| 危险类别码 | 20/21/22-36/37/38 |
| 安全说明 | 26-36/37 |