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| | AM-6494 Basic information |
| Product Name: | AM-6494 | | Synonyms: | AM-6494;AM6494,AM 6494;2-Pyrazinecarboxamide, N-[3-[(1S,5S,6S)-3-amino-1-(methoxymethyl)-5-methyl-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-(2-propyn-1-yloxy)- | | CAS: | 1874232-80-0 | | MF: | C22H21F2N5O3S | | MW: | 473.5 | | EINECS: | | | Product Categories: | | | Mol File: | 1874232-80-0.mol |  |
| | AM-6494 Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | pka | 8.01±0.70(Predicted) |
| | AM-6494 Usage And Synthesis |
| Description | AM-6494 is a Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. | | Uses | AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1]. AM-6494 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | BACE1 | | References | [1] Pettus LH, Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. J Med Chem. 2019 Oct 18. DOI:10.1021/acs.jmedchem.9b01034 |
| | AM-6494 Preparation Products And Raw materials |
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