| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:MitoPBN
CAS:652968-37-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Basic information |
| | 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml | | form | A solid | | color | White to off-white |
| | 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Usage And Synthesis |
| Description | MitoPBN is a mitochondria-targeted antioxidant.1 It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria. | | Uses | MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria. | | References | 1. Murphy, M.P., Echtay, K.S., Blaikie, F.H., et al. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria-targeted spin trap derived from α-phenyl-N-tert-butylnitrone J. Biol. Chem. 278(49),48534-48545(2003). |
| | 4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE Preparation Products And Raw materials |
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