| Company Name: |
Shanghai Merlot Chemical Co., LTD
|
| Tel: |
15821661757 |
| Email: |
226174156@qq.com |
| Products Intro: |
Product Name:1H-Pyrazol-5-ol, 1-(5-chloro-2-pyridinyl)-3-phenyl-
CAS:2579696-72-1
Purity:95% Package:1g；5g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:COQ7-IN-1
CAS:2579696-72-1
Purity:95% Package:2mg;5mg;1mL
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:COQ7-IN-1
CAS:2579696-72-1
Package:5mg/RMB 869;2mg/RMB 497
|
1H-Pyrazol-5-ol, 1-(5-chloro-2-pyridinyl)-3-phenyl- manufacturers
- COQ7-IN-1
-
- $58.00 / 2mg
-
2025-10-27
- CAS:2579696-72-1
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | 1H-Pyrazol-5-ol, 1-(5-chloro-2-pyridinyl)-3-phenyl- Basic information |
| | 1H-Pyrazol-5-ol, 1-(5-chloro-2-pyridinyl)-3-phenyl- Chemical Properties |
| Boiling point | 482.3±45.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 100 mg/mL (368.05 mM; Need ultrasonic) | | form | Solid | | pka | 6.77±0.50(Predicted) | | color | Off-white to light yellow |
| | 1H-Pyrazol-5-ol, 1-(5-chloro-2-pyridinyl)-3-phenyl- Usage And Synthesis |
| Uses | COQ7-IN-1, a highly potent inhibitor of human coenzyme Q (COQ7), interferes with ubiquinone (UQ) synthesis. COQ7-IN-1 does not disturb physiological cell growth of human normal culture cells. COQ7-IN-1 can be used for the research of the balance between UQ supplementation pathways: de novo UQ synthesis and extracellular UQ uptake[1]. | | Biological Activity | COQ7-IN-1, a highly potent inhibitor of human coenzyme Q (COQ7), interferes with ubiquinone (UQ) synthesis. COQ7-IN-1 does not disturb physiological cell growth of human normal culture cells. COQ7-IN-1 can be used for the research of the balance between UQ supplementation pathways: de novo UQ synthesis and extracellular UQ uptake[1].
COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cells growth with a GI50 of 19.0 μM. COQ7-IN-1 weakly inhibits C3A cells growth with GI50 of 9.0±1.1 μM. COQ7-IN-1 does not limit C3A cell survival through inhibiting aerobic respiration or increasing oxidative stress[1].COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), and then converted to UQ by COQ3. Cells under COQ7 deficiency are unable to produce UQ, and consequently accumulate DMQ. DMQ10 and UQ10 contents in each culture well are 13.2 and 12.2 ng/well for COQ7-IN-1 (10 μM; for 2 days) cultured with HeLa cells. DMQ10 content of COQ7-IN-1 in HeLa cells is 52.0%[1]. | | References | [1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182. |
| | 1H-Pyrazol-5-ol, 1-(5-chloro-2-pyridinyl)-3-phenyl- Preparation Products And Raw materials |
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