COQ7-IN-1 NEW
| Price | $58 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: COQ7-IN-1 | CAS No.: 2579696-72-1 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | COQ7-IN-1 |
| Description | COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1]. |
| In vitro | COQ7-IN-1 (Compound 8; 0-30 μM; for 4 days) inhibits WI-38 cell growth with a GI50 of 19.0 μM and weakly inhibits C3A cell growth with a GI50 of 9.0±1.1 μM, without affecting C3A cell survival via inhibition of aerobic respiration or increased oxidative stress[1]. COQ7 converts demethoxy-UQ (DMQ) to demethyl-UQ (DMeQ), which is then converted to UQ by COQ3. Cells deficient in COQ7 cannot produce UQ, leading to DMQ accumulation. DMQ10 and UQ10 contents in COQ7-IN-1 (10 μM; for 2 days) cultured HeLa cells are 13.2 and 12.2 ng/well, respectively, with a DMQ10 content of 52.0%[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (368.05 mM), Sonication is recommended. |
| Keywords | COQ-7-IN-1 | COQ7 IN 1 | COQ7IN1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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