5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-

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5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Suppliers list
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5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Basic information
Product Name:5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-
Synonyms:5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-;HPK1-IN-4;4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-5-Pyrimidinecarboxamide;4-{[2-(hydroxymethyl)phenyl]amino}-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide;HPK1-IN-4, 10 mM in DMSO
CAS:2739844-28-9
MF:C23H26N6O3
MW:434.49
EINECS:
Product Categories:
Mol File:2739844-28-9.mol
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Structure
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Chemical Properties
Boiling point 694.9±65.0 °C(Predicted)
density 1.347±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka13.93±0.50(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Usage And Synthesis
UsesHPK1-IN-4 (comp 22) is a HPK1 (MAPK41) inhibitor (IC50 of 0.061 nM) as preclinical immunoresearch tool compound[1].
Biological ActivityHPK1-IN-4 (comp 22) is a HPK1 (MAPK41) inhibitor (IC50 of 0.061 nM) as preclinical immunotherapy tool compound[1].
References[1]. Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661.
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- Preparation Products And Raw materials
Tag:5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-(2739844-28-9) Related Product Information
5-Pyrimidinecarboxamide, 4-[[2-(hydroxymethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- 5-Pyrimidinecarboxamide, 4-[[2-fluoro-6-(trifluoromethyl)phenyl]amino]-2-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]- 2-[[2-(4-Hydroxy-3-methoxyphenyl)ethyl]amino]-4-[(3-methylphenyl)amino]-5-pyrimidinecarboxamide FMF-06-098-1 2-Pyridinamine, 5-[2-(4-piperidinyl)-5-thiazolyl]-3-(4-pyridinylmethoxy)- BenzaMide, N-[4-[(4-ethyl-1-piperazinyl)Methyl]-3-(trifluoroMethyl)phenyl]-4-Methyl-3-[(6-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-yl)oxy]-