|
|
| | 2-CHLORO-4-HYDROXYBENZONITRILE Basic information | | Uses |
| | 2-CHLORO-4-HYDROXYBENZONITRILE Chemical Properties |
| Melting point | 160 °C (dec.)(lit.) | | Boiling point | 323.2±27.0 °C(Predicted) | | density | 1.41±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 6.88±0.18(Predicted) | | form | powder | | color | White | | InChIKey | BDDVAWDNVWLHDQ-UHFFFAOYSA-N | | CAS DataBase Reference | 3336-16-1 |
| | 2-CHLORO-4-HYDROXYBENZONITRILE Usage And Synthesis |
| Uses | 2-Chloro-4-hydroxybenzonitrile is used for preparation of arylthioamides. | | Chemical Properties | white to light yellow crystal powder | | Uses | 2-Chloro-4-hydroxybenzonitrile may be used in the synthesis of 6-aminophenanthridines via Suzuki-Miyaura coupling reaction. It may be used in the preparation of 5-bromo-2-chloro-4-hydroxybenzonitrile. | | Synthesis | Step 5: 2-Chloro-4-aminobenzonitrile (25 g, 0.187 mol) was added to a stirred mixture of concentrated sulfuric acid (58 g) and water (570 mL) and heated between 49 °C and 61 °C for about 30 minutes. The suspension was cooled to about 0°C and a cold solution of sodium nitrite (13.2 g, 0.187 mol) dissolved in water (125 mL) was slowly added dropwise over a temperature range of 0°C to 6°C. After the dropwise addition was completed, stirring of the reaction mixture was continued for about 3 hours. Subsequently, urea (1.5 g) was added to the mixture to quench the excess sodium nitrite. Insoluble impurities were removed by filtration. To the filtrate was added a 50% aqueous sulfuric acid solution (600 mL) while the reaction mixture was heated to between 74 °C and 81 °C with continuous stirring until the nitrogen stopped escaping. Upon completion of the reaction, the product was separated by filtration and purified with recrystallized water to give 2-chloro-4-hydroxybenzonitrile (17.9 g, 62.5% yield, melting point 160 °C). | | References | [1] Patent: US4424371, 1984, A |
| | 2-CHLORO-4-HYDROXYBENZONITRILE Preparation Products And Raw materials |
|