Quinupristin-dalfopristin

Quinupristin-dalfopristin Suppliers list
Company Name: BOC Sciences
Tel: 1-631-485-4226
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Products Intro: Product Name:Quinupristin-Dalfopristin mesylate complex
CAS:126602-89-9
Purity:>98%
Company Name: ChemStrong Scientific Co.,Ltd  
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Products Intro: Product Name:Quinupristin-Dalfopristin mesylate complex
CAS:126602-89-9
Purity:>98% by HPLC Package:5mg,25mg
Company Name: ShangHai Biochempartner Co.,Ltd  
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Products Intro: Product Name:Quinupristin-dalfopristin
CAS:126602-89-9
Purity:98% HPLC LCMS Package:100mg;500mg;1g;5g;10g
Company Name: Novachemistry  
Tel: +44 (0)208 191 7890
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Products Intro: Product Name:Quinupristin-Dalfopristin mesylate complex
CAS:126602-89-9
Purity:>98% by HPLC Package:1mg;5mg
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: 400-002-6226
Email: sales@biochemall.cn
Products Intro: Product Name:Quinupristin-Dalfopristin mesylate complex
CAS:126602-89-9
Quinupristin-dalfopristin Basic information
Product Name:Quinupristin-dalfopristin
Synonyms:Quinupristin-dalfopristin;SYNERCID;Quinupristin-Dalfopristin Mesylate coMplex;Synercid coMplex, Dalfopristin-Quinupristin coMplex;Mixture with quinupristin;Quinipristine+ Dalfopristin Mesylate
CAS:126602-89-9
MF:C53H67N9O10S.C34H50N4O9S
MW:1713.09
EINECS:
Product Categories:
Mol File:126602-89-9.mol
Quinupristin-dalfopristin Structure
Quinupristin-dalfopristin Chemical Properties
Safety Information
MSDS Information
Quinupristin-dalfopristin Usage And Synthesis
DescriptionDalfopristin and Quinupristin are two well-defined semi-synthetic antibacterials belonging to the class of streptogramins. Together, they form Synercid, an injectable formulation in a ratio 70 : 30 that was launched in the UK followed by the US. The two distinct antibiotic agents, pristinamycins, are bacteriostatic in their own right but, when they are in association, act synergistically at the ribosomal level to inhibit protein synthesis. Synercid is the first antibiotic in its class to reach the market. It appears to be a sound treatment alternative for patients with severe or life-threatening infections, such as the most problematic forms of gram-positive nosocomial sepsis including vancomycin-resistant Enterococcus faecium (VREF) or methicillinresistant Staphylococcus aureus (MRSA).
OriginatorRhone-Poulenc-Rorer (France)
UsesQuinupristin-dalfopristin mesylate complex is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as SynercidTM. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.
Brand nameSynercid
Quinupristin-dalfopristin Preparation Products And Raw materials
Tag:Quinupristin-dalfopristin(126602-89-9) Related Product Information
AC-D-PRO-OH N-[(1-BUTYL-2-PIPERIDINYL)METHYL]ETHANAMINE METHOXYCARBONYLETHYL-ETHYLSULFONE Virginiamycin S1 L-ALANYL-L-ALANYL-L-ALANINE METHYL ESTER ACETATE (R)-(+)-2-(METHOXYMETHYL)-1-PYRROLIDINECARBOXALDEHYDE 1-BUTYL-4-PIPERIDONE DIISOBUTYL SULFIDE 4-[N-Methyl-4-(methylamino)-L-phenylalanine]virginiamycin S1 N-(1-phenylethyl)piperidine-2-carboxamide ETHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE Dalfopristin AC-PHG-OME Quinupristin-dalfopristin (S)-ALPHA-AMINOBENZENEACETIC ACID ETHYL ESTER N-benzylpiperidine-2-carboxamide Quinupristin 1-butyrylpiperidin-4-one