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3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE

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3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Suppliers list
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:MDM2 inhibitor
CAS:562823-84-1
Purity:>=95% Package:$155.9/10mg;Bulk package Remarks:95%
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem
Company Name: Shanghai Haohong Scientific Co., Ltd.  
Tel: 400-400-8210725
Email: malulu@leyan.com
Products Intro: Product Name:MDM2-IN-20
CAS:562823-84-1
Purity:98%
Company Name: Yantai Lianhua Technology Co., Ltd  
Tel: 15552437730
Email: 1701654643@qq.com
Products Intro: Product Name:trans-4-iodo-4'-boranyl-chalcone
CAS:562823-84-1
Purity:95%+ Package:50G;100G
Company Name: Shanghai Aladdin Biochemical Technology Co.,Ltd.  
Tel: +86-18521732826
Email: market@aladdin-e.com
Products Intro: Product Name:MDM2 inhibitor
CAS:562823-84-1
Purity:>=95% Package:10mg/RMB 1144.90
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Basic information
Product Name:3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE
Synonyms:3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE;3-(4-IODO-PHENYL)-1-(4''- BORANYL-PHENYL)-PROP-2-ENONE (FOR R&D ONLY);TRANS-4-IODO,4'-BORANYL-CHALCONE;MDM2 Inhibitor;MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem;Boronic acid, B-[4-[(2E)-3-(4-iodophenyl)-1-oxo-2-propen-1-yl]phenyl]-;MDM2-IN-20
CAS:562823-84-1
MF:C15H12BIO3
MW:377.97
EINECS:
Product Categories:Cell Cycle RegulatorsImmune Cell Signaling and Blood;Apoptosis and Cell Cycle;Cell Cycle;Immune System Regulation;Immunomodulators and Antibiotics
Mol File:562823-84-1.mol
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Structure
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Chemical Properties
storage temp. +2C to +8C
solubility DMSO: >30 mg/mL, soluble
form solid
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Usage And Synthesis
DefinitionChEBI: [4-[3-(4-iodophenyl)prop-2-enoyl]phenyl]boronic acid is a member of chalcones.
General DescriptionA cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 μM for MDA-MB-435, 8.8 μM for MDA-MB-231, and 7 μM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 μM for MCF-10A and 63 μM for MCF-12A).
Biochem/physiol ActionsCell permeable: yes
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE Preparation Products And Raw materials
Tag:3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE(562823-84-1) Related Product Information
3-(4-IODO-PHENYL)-1-(4'-BORANYL-PHENYL)-PROP-2-ENONE 4-Carboxyphenylboronic acid