Company Name: |
Suzhou Meishi Biotechnology Co., Ltd.
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Tel: |
1173954148q |
Email: |
meishipharma@126.com |
Products Intro: |
Product Name:132373-81-0 CAS:132373-81-0 Purity:99% HPLC Package:1G;5G;10G;100G;1KG;
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Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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Tel: |
021-65675885 18964387627 |
Email: |
customer_service@efebio.com |
Products Intro: |
Product Name:Vamicamide CAS:132373-81-0 Purity:99.81% Package:1mg;5mg;10mg
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Company Name: |
TargetMol Chemicals Inc.
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Tel: |
15002134094 |
Email: |
marketing@targetmol.cn |
Products Intro: |
Product Name:Vamicamide CAS:132373-81-0 Purity:0 Package:1mg
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| VAMICAMIDE Basic information |
Product Name: | VAMICAMIDE | Synonyms: | 2-Pyridineacetamide, α-[(2R)-2-(dimethylamino)propyl]-α-phenyl-, (αR)-rel-;FK 176|||FK-176|||FK176 | CAS: | 132373-81-0 | MF: | C18H23N3O | MW: | 297.39 | EINECS: | | Product Categories: | | Mol File: | 132373-81-0.mol | |
| VAMICAMIDE Chemical Properties |
| VAMICAMIDE Usage And Synthesis |
Originator | Vamicamide,Fujisawa Pharmaceutical | Uses | Antiepileptic; anticonvulsant. | Manufacturing Process | Conc. sulfuric acid (11 ml) was added to 4-(N,N-dimethylamino)-2-phenyl-2-
(2-pyridyl)-valeronitrile (6.3 g) at 0°C. Then water (1 ml) was added thereto.
After being heated at 90°C for 3 hours, the mixture was poured into ice-water,
adjusted to pH 10 with 10% aqueous sodium hydroxide and extracted with
ethyl acetate (3x50ml). The extracts were combined, and washed with water,
dried over magnesium sulfate and evaporated under reduced pressure. The
obtained crude crystal was recrystallized from diethyl ether to give 4-(N,N_x0002_dimethylamino)-2-phenyl-2-(2-pyridyl)-valeramide (1.89 g). MP: 132-134°C.
Recrystallization from 40% water ethanol gave MP: 156-157°C. The structure
of the product was confirmed by UR, NMR (CDCl3) spectra and elemental
analysis. | Therapeutic Function | Anticholinergic, Spasmolytic |
| VAMICAMIDE Preparation Products And Raw materials |
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