(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate

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(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate Basic information
Product Name:(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate
Synonyms:J 104129 FUMARATE;(αR)-α-Cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamidefumarate;Benzeneacetamide, α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-penten-1-yl)-4-piperidinyl]-, (αR)-;(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate
CAS:244277-89-2
MF:C24H36N2O2
MW:384.55
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Mol File:244277-89-2.mol
(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate Structure
(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate Chemical Properties
storage temp. Store at +4°C
solubility <50.06mg/ml in DMSO; <25.03mg/ml in ethanol
Safety Information
MSDS Information
(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate Usage And Synthesis
UsesJ 104129 is a mAChR M3 antagonist.
Biological ActivityPotent M 3 muscarinic receptor antagonist that displays ~ 120-fold selectivity over M 2 receptors (K i values are 4.2, 19 and 490 nM for human M 3 , M 1 and M 2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (K B values are 3.3 and 170 nM for rat trachea M 3 and rat right atria M 2 receptors respectively).
in vivo

J-104129 (10 mg/kg; p.o.; single) shows durable bronchodilatory action lasting over 10 h in rats[1][2].
J-104129 (p.o.) antagonizes ACh-induced bronchoconstriction with an ED50 value of 0.58 mg/kg in rats[1].

Animal Model:Male Sprague-Dawley rats[1][2].
Dosage:10 mg/kg
Administration:Oral administration; single.
Result:Exhibited bronchodilatory activity.
(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate Preparation Products And Raw materials
Tag:(αR)-α-cyclopentyl-α-hydroxy-N-[1-(4-methyl-3-pentenyl)-4-piperidinyl]benzeneacetamide fumarate(244277-89-2) Related Product Information
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