人参皂苷 RK3
中文名称 | 人参皂苷 RK3 |
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中文同义词 | 人参皂苷 RK3;人参皂苷RK3,R1=葡萄糖;人参皂甙RK3;人参皂苷RK3(人参皂甙RK3);人参皂苷RK3(标准品);人参皂苷RK3对照品 |
英文名称 | Ginsenoside Rk3 |
英文同义词 | Ginsenoside Rk3;Ginsenoside Rk3 standard;β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl |
CAS号 | 364779-15-7 |
分子式 | C36H60O8 |
分子量 | 620.87 |
EINECS号 | |
植物来源 | 人参 |
相关类别 | 植物提取物;中药对照品;植提标准品;对照品;标准品;分析试剂标准品;标准品-对照品;对照品-中药对照品;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 364779-15-7.mol |
结构式 |
人参皂苷 RK3 性质
沸点 | 722.4±60.0 °C(Predicted) |
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密度 | 1.20±0.1 g/cm3 (20 ºC 760 Torr) |
储存条件 | 4°C, protect from light |
溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
形态 | 粉末 |
酸度系数(pKa) | 12.91±0.70(Predicted) |
颜色 | 白色至米白色 |
NF-κB 14.24 μM (IC 50 , in HepG2 cells) |
NF-κB 15.32 μM (IC 50 , in SK-Hep1 cell) |
Ginsenoside Rk3 exerts the strong activity inhibiting NF-κB in a dose-dependent manner. HepG2 cells are pre-treated with different ginsenosides at concentrations ranging from 0.01 to 10 μM for 1 h, and induced with TNF-α for 20 h. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC 50 of 14.24±1.30 μM. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC 50 of 15.32±0.29 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Consistent with the inhibition of NF-κB, Ginsenoside Rk3 inhibits the induction of IL8 , CXCL1 , iNOS , and ICAM1 mRNA significantly in a dose-dependent manner.
The inhibitory effects of Ginsenoside Rk3 (Rk3) on tumor progression are studied in vivo using a H460 xenograft model in nude mice. Compared with the control group, a significant inhibition of tumor growth (volume) is observed in the Ginsenoside Rk3-treated group. Twenty-one days after treatment initiation, tumor growth is significantly inhibited by approximately 62.99% in the mice receiving 20 mg/kg Ginsenoside Rk3, similar to the inhibitory effect observed in the 20 mg/kg Gefitinib-treated group (57.21%). Compared with the control group, tumor growth is moderately inhibited in the mice receiving 10 and 5 mg/kg Ginsenoside Rk3, with inhibition rates of 32.54% and 11.84%, respectively.
药理药效:可能有心血管、按肿瘤方面的活性
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N0906 | Ginsenoside Rk3 | 1 mg | 838元 | |
2024/08/19 | HY-N0906 | 人参皂苷 RK3 Ginsenoside Rk3 | 364779-15-7 | 5mg | 2200元 |