| Company Name: |
MedChemexpress LLC
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021-58955995 |
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sales@medchemexpress.cn |
| Products Intro: |
Product Name:SA4503
CAS:165377-43-5
Purity:>98% Package:1190RMB/10mg
|
| Company Name: |
LETOPHARM LIMITED
|
| Tel: |
+86-21-5821 5861 |
| Email: |
sales@letopharm.com |
| Products Intro: |
Product Name:SA4503
CAS:165377-43-5
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| | 1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE Basic information |
| | 1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE Chemical Properties |
| Boiling point | 499.2±45.0 °C(Predicted) | | density | 1.053±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO | | pka | 7.61±0.10(Predicted) |
| | 1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE Usage And Synthesis |
| Uses | Cutamesine (SA4503; AGY-94806) is a selective sigma 1 receptor(σ1R) agonist; high affinity for the sigma 1 receptor (IC50= 17.4±1.9 nM); 100-fold less affinity for the sigma 2 receptor. | | IC 50 | Sigma 1 Receptor | | References | [1] Matsuno K, et al. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol. 1996 Jun 13;306(1-3):271-9. DOI:10.1016/0014-2999(96)00201-4
[2] Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33(2):129-40. DOI:10.1002/(SICI)1098-2396(199908)33:23.0.CO;2-E
[3] Ono Y, et al. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neurosci Lett. 2014 Jan 24;559:174-8. DOI:10.1016/j.neulet.2013.12.005 |
| | 1-[2-(3,4-DIMETHOXYPHENYL)ETHYL]-4-(3-PHENYLPROPYL)PIPERAZINE Preparation Products And Raw materials |
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