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| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Basic information |
| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Chemical Properties |
| Melting point | >300 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3)) | | Boiling point | 543.0±40.0 °C(Predicted) | | density | 1.506±0.06 g/cm3(Predicted) | | pka | 11.81±0.20(Predicted) |
| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Usage And Synthesis |
| Description | Ellipticine quinone, also known as NSC-383230, is a Drp1 inhibitor. rpitor1 and Drpitor1a inhibited the GTPase activity of Drp1 without inhibiting the GTPase of dynamin 1. Ellipticine quinone showed greater potency than the current std. Drp1 GTPase inhibitor, mdivi-?1, (IC50 for mitochondrial fragmentation are (0.06, and 10 μM, resp.)?. Ellipticine quinone suppressed lung cancer tumor growth in a mouse xenograft model. Ellipticine quinone also inhibited mitochondrial ROS prodn., prevented mitochondrial fission, and improved right ventricular diastolic dysfunction during IR injury. |
| | 5H-Pyrido[4,3-b]carbazole-5,11(6H)-dione Preparation Products And Raw materials |
| Raw materials | 1H-Indole-3-carboxylic acid, 2-(4-pyridinylcarbonyl)-, ethyl ester-->1H-Indole-3-carboxylic acid, 2-(4-pyridinylcarbonyl)--->5H-Pyrido[4',3':5,6]oxepino[3,2-b]indol-5-one, 6,12-dihydro--->1H-Indole-2-carboxylic acid, 3-(3-pyridinylcarbonyl)-, ethyl ester-->N-(methoxymethyl)-3-indolecarboxaldehyde-->sodiuM 2-(2-aMinophenyl)-2-oxoacetate-->Isatin-->Indole-3-carboxaldehyde-->Indole | | Preparation Products | 5H-Pyrido[3,4-b]carbazole-5,11(10H)-dione |
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