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Indole

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Company Name: Frapp's ChemicalNFTZ Co., Ltd.
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Products Intro: Product Name:Indole
CAS:120-72-9
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Email: Abel@chembj.com
Products Intro: Product Name:Indole
CAS:120-72-9
Purity:99% Package:116/KG
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Indole
CAS:120-72-9
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
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Products Intro: CAS:120-72-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
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Email: sales@mainchem.com
Products Intro: Product Name:Indole
CAS:120-72-9

Lastest Price from Indole manufacturers

  • Indole
  • US $3500.00 / KG
  • 2019-04-01
  • CAS:120-72-9
  • Min. Order: 25KG
  • Purity: 99.5%
  • Supply Ability: 50tons
Indole Chemical Properties
Melting point 51-54 °C(lit.)
Boiling point 253-254 °C(lit.)
density 1.22
vapor pressure 0.016 hPa (25 °C)
FEMA 2593 | INDOLE
refractive index 1.6300
Fp >230 °F
storage temp. 2-8°C
solubility methanol: 0.1 g/mL, clear
form Crystalline Powder
color White to slightly pink
PH5.9 (1000g/l, H2O, 20℃)
Water Solubility 2.80 g/L (25 ºC)
Sensitive Light Sensitive
Merck 14,4963
JECFA Number1301
BRN 107693
Stability:Stable, but may be light or air sensitive. Incompatible with strong oxidizing agents, iron and iron salts.
CAS DataBase Reference120-72-9(CAS DataBase Reference)
NIST Chemistry ReferenceIndole(120-72-9)
EPA Substance Registry System1H-Indole(120-72-9)
Safety Information
Hazard Codes Xn,N,T
Risk Statements 21/22-37/38-41-50/53-36-39/23/24/25-23/24/25-52/53
Safety Statements 26-36/37/39-60-61-45-36/37
RIDADR UN 2811 6.1/PG 3
WGK Germany 1
RTECS NL2450000
8-13
TSCA Yes
HS Code 2933 99 20
HazardClass 9
PackingGroup III
Hazardous Substances Data120-72-9(Hazardous Substances Data)
ToxicityLD50 orally in rats: 1 g/kg (Smyth)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
Indole Usage And Synthesis
descriptionIndole, also called Benzopyrrole, an aromatic heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. It can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal smell. This off flavour occurs in beer due to contaminant coliform bacteria during the primary fermentation stage of beer brewing. At very low concentrations, however, it has a flowery smell, and is a constituent of many flower scents (such as orange blossoms) and perfumes. Natural jasmine oil, used in the perfume industry, contains around 2.5% of indole. Indole also occurs in coal tar. The participation of the nitrogen lone electron pair in the aromatic ring means that indole is not a base, and it does not behave like a simple amine.
Indoles are important precursors for other substances made within the human body and are, therefore, researched and used in lifestyle and medical applications. The compound was officially discovered in 1866 by a scientist working with the properties of zinc dust who reduced oxindole from the zinc dust into an indole. After the discovery, indoles became important constituents of the textile industry, and as more research was conducted, the larger role that indoles played within the human body system was realized. The indolic nucleus in substances like tryptophan and auxin has led to a better understanding of their mechanism within the body.
Content analysisPress GT-10-4 gas chromatography method for the determination with polar column.
Using the polar column method in GT-10-4 gas chromatography to determine the content of indole.
ToxicityGRAS(FEMA)。
LD50 1000 mg/kg(test with rat orally).
Utilization limitationFEMAmg/kg:soft drinks:0.26;cold drinks:0.28;candy:0.50;bakery product :0.58;pudding:0.02~0.40.
Moderate limit (FDA§172.515,2000)
Chemical propertyIt is the shiny flaky white crystals, and would turn into dark colors when it exposed to light. There would be a strong unpleasant odor with high concentration of indole, but the flavor would change into oranges and jasmine after highly diluted (concentration <0.1%). It has the melting point of 52~53 ℃ and the boiling point of 253~254 ℃. It is soluble in alcohol, ether, hot water, propylene glycol, petroleum ether and most of the non-volatile oil, insoluble in glycerin and mineral oil.
Natural indole are widely contained in neroli oil, orange oil, lemon oil, lime oil, citrus oil, peel oil, jasmine oil and other essential oil.
Uses(1) According to the GB 27 60-96 , indole can be used as flavouring agent and mainly used for preparing the essence of cheese, citrus, coffee, nuts, grape, strawberry, raspberry, chocolate, assorted fruit, jasmine and lily etc.
(2) It can be used as the reagent for the determination of nitrite, can also used in the manufacture of perfume and medicine.
(3) It can be used as the raw material of perfume, pharmaceuticals and plant growth hormone.
(4) Indole is the intermediate for the indole acetic acid and indole butyric acid.The indole acetic acid and indole butyric are plant growth regulator.
(5) It can be widely used in the manufacture of the essences of jasmine, lilac, orange blossom, gardenia, honeysuckle, lotus, narcissus, ylang, orchid and prynne etc. It is usually combined with the methyl indole to imitate the artificial civet. The extremely few of the indole can be used in chocolate, raspberry, strawberry, bitter orange, coffee, nuts, cheese, grapes and fruit and other fruity essential oil.
(6) Indole is mainly used as spices, dyes, amino acids and the raw materials of pesticide. Indole itself is a spice commonly used in producing the essences of jasmine, lilac, lotus flowers, orchids and other flower flavor. The usage is generally in a few thousandths.
(7) It can be used for verifying the gold, potassium and nitrite and manufacturing jasmine-type fragrance. It can also be used in pharmaceutical industry.
Chemical Propertieswhite crystals with an unpleasant odour
UsesCan be used in perfumes and in the synthesis of tryptophan.
UsesIndole is a flavoring agent that is a white, flaky crystalline product. it has an unpleasant odor when concentrated and a flowery odor when diluted. it is soluble in most fixed oils and propylene glycol and insoluble in glycerin and mineral oil. it is obtained from decomposi- tion of a protein.
UsesIndole occurs in coal tar. It is used, underhigh dilution, in perfumery, and as an intermediatein organic synthesis.
Definitionindole: A yellow solid, C8H7N, m.p.52°C. Its molecules consist of a benzenering fused to a nitrogen-containingfive-membered ring. It occurs insome plants and in coal tar, and isproduced in faeces by bacterial action.It is used in making perfumes.Indole has the nitrogen atom positionednext to the fused benzenering. An isomer with the nitrogentwo atoms away from the fused ringis called isoindole.
UsesIn highly dil solutions the odor is pleasant, hence indole has been used in perfumery.
HazardA carcinogen.
Health HazardLow to moderate toxicity was observed inexperimental animals resulting from oral orsubcutaneous administration of indole. Theoral LD50 value in rats is 1000 mg/kg. It is ananimal carcinogen. It caused tumors in bloodand lungs in mice subjected to subcutaneousadministration.
Fire HazardNoncombustible solid.
Metabolic pathwayThe indole is metabolized in a mineral salt medium inoculated with 9% anaerobically digested nitrate- reducing sewage sludge, resulting in the sequential occurrence of four structurally related compounds: oxindole, isatine, dioxindole, and anthranilic acid. Indole is metabolized by fungus via indoxyl (3-hydroxyindole), N-formylanthranilic acid, anthranilic acid, 2,3-dihydroxybenzoic acid, and catecol, which is further degraded by an ortho cleavage.
Purification MethodsIt can be further purified by sublimation in a vacuum or by zone melting. The picrate forms orange crystals from EtOH and has m 175o. [Beilstein 20 II 196, 20 III/IV 3176, 20/7 V 5.]
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