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| | GSK2838232 Basic information |
| Product Name: | GSK2838232 | | Synonyms: | GSK2838232;(3beta)-3-(3-Carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-28-norlup-18-en-21-one;GSK-2838232A; GSK 2838232A;CS-947;GSK2838232(GSK2838232A);HIV Inhibitor GS2838232;28-Norlup-18-en-21-one, 3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(3-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-, (3β)-;EX-A202 | | CAS: | 1443461-21-9 | | MF: | C48H73ClN2O6 | | MW: | 809.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1443461-21-9.mol |  |
| | GSK2838232 Chemical Properties |
| Boiling point | 817.1±65.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Powder | | pka | 4.48±0.28(Predicted) |
| | GSK2838232 Usage And Synthesis |
| Biological Activity | gsk2838232 is an hiv-1 maturation inhibitor [1] [2].hiv-1 maturation inhibitors disrupt the cleavage of the hiv-1 gag protein immediate precursor by the enzyme hiv-1 protease. maturation inhibitors bind the gag protein, which leads to the formation of immature, noninfectious virus particles incapable of infecting other cells. also, maturation inhibitors inhibit hiv infections with resistance.gsk2838232 is a hiv-1 maturation inhibitor and is active against a broad range of isolates, including those resistant to bevirimat [1]. gsk2838232 was developed for the treatment of chronic hiv infection. a phase i study in hiv-negative individuals had been completed. single doses of 5, 10 or 20 mg gsk2838232 were used to evaluate the initial safety, tolerability, pharmacokinetics profile, and the effects of food and ritonavir on gsk2838232’s bioavailability and pharmacokinetics [2]. | | references | [1]. olender sa, taylor bs, wong m, et al. croi 2015: advances in antiretroviral therapy. croi 2015 highlights: antiretroviral therapy volume 23 issue 1 march/april 2015.
[2]. horn t, collins s. the antiretroviral pipeline. antiretrovirals, 2014 pipeline report. |
| | GSK2838232 Preparation Products And Raw materials |
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