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| | GSK2795039 Basic information |
| Product Name: | GSK2795039 | | Synonyms: | GSK2795039;N-(1-isopropyl-3-(1-methylindolin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide;GSK-2795039
(GSK 2795039;1H-Pyrazole-3-sulfonamide, N-[3-(2,3-dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-;Inhibitor,Reactive Oxygen Species,NADPH Oxidase,NOX,inhibit,Apoptosis,GSK-2795039,GSK2795039,GSK 2795039 | | CAS: | 1415925-18-6 | | MF: | C23H26N6O2S | | MW: | 450.56 | | EINECS: | | | Product Categories: | | | Mol File: | 1415925-18-6.mol |  |
| | GSK2795039 Chemical Properties |
| Boiling point | 691.5±65.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF:30.0(Max Conc. mg/mL);66.58(Max Conc. mM)
DMSO:66.27(Max Conc. mg/mL);147.07(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.44(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);44.39(Max Conc. mM) | | form | A solid | | pka | 6.99±0.30(Predicted) |
| | GSK2795039 Usage And Synthesis |
| Biological Activity | GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. It inhibits reactive oxygen species (ROS) production, NADPH depletion and reduces apoptosis. | | in vitro | GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells. Apoptosis Analysis p> | Cell Line: | PC12 cells | < td class="col1"> Concentration: | 25 μM | | Incubation Time: | < td class="col2"> 24 hours | Result: | Reduced apoptosis among PC12 cells. | td> | | target | | Target | Value | ROS
() | | NADPH
() | | NOX2 (HRP/Amplex Red)
(Cell-based assay) | 6.57( pIC50) |
| | storage | Store at -20°C |
| | GSK2795039 Preparation Products And Raw materials |
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