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| | Propargyl-PEG3-NHS ester Basic information |
| Product Name: | Propargyl-PEG3-NHS ester | | Synonyms: | Propargyl-PEG3-NHS ester;Alkyne-PEG3-NHS;Propargyl-PEG2-CH2CH2COONHS;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propargyl-PEG2-Osu;Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG2-C2-CONHS ester | | CAS: | 1428629-71-3 | | MF: | C14H19NO7 | | MW: | 313.3 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1428629-71-3.mol |  |
| | Propargyl-PEG3-NHS ester Chemical Properties |
| Boiling point | 427.2±55.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | InChI | InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2 | | InChIKey | YDRPXORAOIYIGV-UHFFFAOYSA-N | | SMILES | C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C |
| | Propargyl-PEG3-NHS ester Usage And Synthesis |
| Description | Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc. | | Biological Activity | Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | | in vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | | target | | Cleavable | PEGs | Alkyl/ether | |
| | Propargyl-PEG3-NHS ester Preparation Products And Raw materials |
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